Cefepim in prophylaxis of infectional complications in cesarean section in risk groups

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Abstract

The efficiency and economical value of infectional surgical complications prophylaxis is considered. The risk factors included diabetes, obesity, pyelonephritis and complicated obstetrical anamnesis. The randomized trial has shown a high effectiveness of Cefepim usage administered intravenously 1.0 during CS and 8 hours later. As a standard we used Cefotaxime (2,0 gr. per day), ampicillin (4,0 qid) and gentamyein (0,24 tid). We estimated the surgical wound condition, body temperature, vaginal discharge. The effectiveness of Cefepim has made 98%. The normalization of parameters was seen up to 4-5 postoperative days.

About the authors

E. K. Ailamazyan

Ott Research Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences; Institute of Pharmacology, Pavlov State Medical University

Email: info@eco-vector.com
Russian Federation, St. Petersburg; St. Petersburg

O. l. Karpov

Ott Research Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences; Institute of Pharmacology, Pavlov State Medical University

Email: info@eco-vector.com
Russian Federation, St. Petersburg; St. Petersburg

M. A. Kutcherencko

Ott Research Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences; Institute of Pharmacology, Pavlov State Medical University

Email: info@eco-vector.com
Russian Federation, St. Petersburg; St. Petersburg

A. A. Zaitcev

Ott Research Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences; Institute of Pharmacology, Pavlov State Medical University

Email: info@eco-vector.com
Russian Federation, St. Petersburg; St. Petersburg

U. D. Ignatov

Ott Research Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences; Institute of Pharmacology, Pavlov State Medical University

Author for correspondence.
Email: info@eco-vector.com
Russian Federation, St. Petersburg; St. Petersburg

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Supplementary files

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1. JATS XML
2. Graph 1. Dependence of cefepime plasma concentration on time and its relationship with MIC90.

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