Progesterone-related changes in pro-inflammatory cytokines in recurrent miscarriage

Habitual miscarriage (RMP) is a multifactorial, genetically determined disease. The NSP problem remains one of the most pressing problems in obstetrics and gynecology, as it entails not only a decrease in the birth rate, but also has a negative impact on the reproductive health of women. The frequency of spontaneous miscarriages ranges from 15 to 20% of desired pregnancies (Sidelnikova V.M., 2002). According to the Collegium of the Ministry of Health of the Russian Federation (2002), 50% of miscarriages occur in the first trimester, 25% of them occur in PNL. Moreover, every fifth desired pregnancy is interrupted spontaneously in the Russian Federation, which leads not only to medical but also demographic losses - 180,000 desired children are not born in the country. In the USA, habitual pregnancy loss (recurrent miscarriage) is diagnosed after three or more spontaneous abortions in a row and is observed in 1% of all married couples (Lee R.M., 2000).