Chromosome 9 inversion infertility treatment. A clinical case

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Abstract

This article presents a clinical case of infertility treatment in a woman with chromosome 9 inversion. We herein analyze the clinical significance of this chromosomal rearrangement and the need for genetic counseling at the stage of pregnancy planning. This communication describes a case of successful infertility treatment using assisted reproductive technology and preimplantation genetic testing of aneuploidy.

About the authors

Svetlana S. Paskar

Mother and Child St. Petersburg Ltd; St. Petersburg Medical and Social Institute

Email: paskarsvetlana@mail.ru
ORCID iD: 0000-0002-9308-3241
SPIN-code: 2010-4379

MD, Cand. Sci. (Med.)

Russian Federation, Saint-Petersburg; Saint Petersburg

Sergei V. Nikitin

Mother and Child St. Petersburg Ltd

Email: snikitine@mail.ru
ORCID iD: 0000-0003-3024-4121

MD, Cand. Sci. (Med.)

Russian Federation, Saint-Petersburg

Marina V. Bogomolova

Mother and Child St. Petersburg Ltd

Email: olsenmar@mail.ru
ORCID iD: 0009-0000-3079-5631

Cand. Sci. (Biol.)

Russian Federation, Saint-Petersburg

Irina S. Fomenkova

Mother and Child St. Petersburg Ltd

Author for correspondence.
Email: rassvet-95@mail.ru

MD, Cand. Sci. (Med.)

Russian Federation, Saint-Petersburg

Elena E. Shutova

St. Petersburg Medical and Social Institute

Email: lenasmirnova1994@yandex.ru
Russian Federation, Saint-Petersburg

References

  1. Mohsen-Pour N, Talebi T, Naderi N, et al. Chromosome 9 inversion: pathogenic or benign? a comprehensive systematic review of all clinical reports. Curr Mol Med. 2022;22(5):385–400. doi: 10.2174/1566524021666210806161128
  2. Liang S, Yang J, Wu H, et al. Effects of chromosome 9 inversion on IVF/ICSI: a 7-year retrospective cohort study. Mol Genet Genomic Med. 2019;7(9). doi: 10.1002/mgg3.856
  3. Abdalla EM, El-Kharadly RN. Pericentric inversion of chromosome 9 in a consanguineous couple with molar pregnancies and spontaneous abortions. Lab Med. 2012;43(5):212–216. doi: 10.1309/LMV84B9GVVYOGZKK
  4. Mozdarani H, Meybodi AM, Karimi H. Impact of pericentric inversion of Chromosome 9 [inv (9) (p11q12)] on infertility. Indian J Hum Genet. 2007;13(1):26–29. doi: 10.4103/0971-6866.32031
  5. Merrion K, Maisenbacher M. Pericentric inversion (Inv) 9 variant-reproductive risk factor or benign finding? J Assist Reprod Genet. 2019;36(12):2557–2561. doi: 10.1007/s10815-019-01601-y
  6. Šípek A Jr, Panczak A, Mihalová R, et al. Pericentric inversion of human chromosome 9 epidemiology study in czech males and females. Folia Biol (Praha). 2015;61(4):140–146.
  7. Kumar M, Thatai A, Chapadgaonkar SS. Homozygosity and heterozygosity of the pericentric inversion of chromosome 9 and its clinical impact. J Clin Diagn Res. 2012;6:816–820.
  8. Muthuvel A, Ravindran M, Chander A, et al. Pericentric inversion of chromosome 9 causing infertility and subsequent successful in vitro fertilization. Niger Med J. 2016;57(2):142–144. doi: 10.4103/0300-1652.182080

Supplementary files

Supplementary Files
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1. JATS XML
2. Figure. The embryo on the sixth day of cultivation in the EmbryoScope+ incubator, recommended for transfer based on the results of preimplantation genetic testing of aneuploidy

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