High activity of MMP-2 and MMP-9 in trophoblast tissue during spontaneous abortion
- Authors: Skorupski P.1, Bogusiewicz M.1, Gogacz M.1, Jerzak M.1, Polak G.1, Tomaszewski J.1, Rechberger T.1
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Affiliations:
- University School of Medicine
- Issue: Vol 48, No 5S (1999)
- Pages: 151-151
- Section: Articles
- URL: https://journals.rcsi.science/jowd/article/view/101438
- DOI: https://doi.org/10.17816/JOWD101438
- ID: 101438
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Abstract
Objective: Extracellular matrix degrading enzymes — matrix metalloproteinases are responsible for many aspects of tissue remodelling. Both matrix metalloproteinase type 2 (MMP-2) and matrix metalloproteinase type 9 (MMP-9) are involved in human implantation and placentation. These enzymes play a crucial role in some pathological processes occurring in the early pregnancy. Low activity of MMP-2 and MMP-9 during trophoblast invasion could lead to the development of preeclamsia. Also, the process of spontaneous abortion may be mediated by increased activity of MMP-2 and MMP-9.
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##article.viewOnOriginalSite##About the authors
P. Skorupski
University School of Medicine
Author for correspondence.
Email: info@eco-vector.com
Poland, Lublin
M. Bogusiewicz
University School of Medicine
Email: info@eco-vector.com
Poland, Lublin
M. Gogacz
University School of Medicine
Email: info@eco-vector.com
Poland, Lublin
M. Jerzak
University School of Medicine
Email: info@eco-vector.com
Poland, Lublin
G. Polak
University School of Medicine
Email: info@eco-vector.com
Poland, Lublin
J. Tomaszewski
University School of Medicine
Email: info@eco-vector.com
Poland, Lublin
T. Rechberger
University School of Medicine
Email: info@eco-vector.com
Poland, Lublin