Neoadjuvant and systemic platinum containing chemotherapy in locally advanced and recurrent carcinoma of the cervix uteri

Abstract

Objective: Locally advanced or recurrent cervical cancer is highly responsive to treatment. Radiation therapy is the mainstay of treatment for patients with this cancer. The role for chemotherapy is as yet unproved and is currently under investigation in the management of these conditions. The rational for neoadjuvant chemotherapy is to induce sufficient tumor response and volume reduction before the tumor vascular supply is compromised by extensive radiation. It is also hoped that it would help reduce and control distant metastases. Also often the only possible treatment available for patients who have recurrent disease or those who present with primary metastatic disease is systemic chemotherapy. The aim of our study was to evaluate the efficacy of chemotherapy in these patients.

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