Механизмы множественной устойчивости бактерий к антибиотикам
- Авторы: Землянко О.М.1,2, Рогоза Т.М.1,3, Журавлева Г.А.1
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Учреждения:
- Санкт-Петербургский государственный университет
- Санкт-Петербургский научный центр Российской академии наук
- Санкт-Петербургский филиал Института общей генетики им. Н.И. Вавилова
- Выпуск: Том 16, № 3 (2018)
- Страницы: 4-17
- Раздел: Генетические основы эволюции экосистем
- URL: https://journals.rcsi.science/ecolgenet/article/view/9063
- DOI: https://doi.org/10.17816/ecogen1634-17
- ID: 9063
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Аннотация
Появление множественной лекарственной устойчивости (МЛУ) ко все более широкому спектру антибиотиков у все большего числа патогенных бактерий представляет на сегодняшний день серьезную угрозу здоровью человечества. Отчасти это связано с бесконтрольным использованием антибиотиков не только в клинической практике, но и в различных отраслях сельского хозяйства. МЛУ обусловлена двумя механизмами: 1) накоплением генов устойчивости в результате интенсивного отбора при действии антибиотиков и 2) активным горизонтальным переносом генов устойчивости. Для понимания причин возникновения полирезистентности бактериальных штаммов к антибиотикам необходимо знание механизмов действия антибиотиков, механизмов возникновения устойчивости к отдельным антибиотикам и механизмов накопления и передачи генов устойчивости между бактериями — всем этим проблемам и посвящен данный обзор.
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Ольга Михайловна Землянко
Санкт-Петербургский государственный университет; Санкт-Петербургский научный центр Российской академии наук
Email: olga_zemlyanko@mail.ru
младший научный сотрудник, кафедра генетики и биотехнологии, биологический факультет
Россия, 199034, г. Санкт-Петербург, Университетская наб., д.7/9; 199034, г. Санкт-Петербург, Университетская наб., 5Татьяна Михайловна Рогоза
Санкт-Петербургский государственный университет; Санкт-Петербургский филиал Института общей генетики им. Н.И. Вавилова
Email: taniuxa@bk.ru
старший преподаватель, кафедра генетики и биотехнологии, биологический факультет
Россия, 199034, г. Санкт-Петербург, Университетская наб., д.7/9; г. Санкт-ПетербургГалина Анатольевна Журавлева
Санкт-Петербургский государственный университет
Автор, ответственный за переписку.
Email: zhouravleva@rambler.ru
д-р биол. наук, профессор, кафедра генетики и биотехнологии, биологический факультет, лаборатория биологии амилоидов
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