Overexpression of genes encoding asparagine-glutamine rich transcriptional factors causes nonsense suppression in Saccharomyces cerevisiae

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Abstract

Previously, we have carried out a search for genes, whose overexpression causes nonsense suppression on the background of modified SUP35 variants expression in yeast Saccharomyces cerevisiae. Here we analyzed the influence of genes encoding N/Q-rich transcriptional factors on this process. We demonstrated that GLN3, MCM1, MOT3 and REB1 genes overexpression affects nonsense suppression in S. cerevisiae

About the authors

Anton Aleksandrovich Nizhnikov

St. Petersburg Branch of Vavilov Institute of General Genetics (Russian Academy of Science)

Email: ant.nizhnikov@gmail.com
Jounior Researcher, Postgraduete student, Deptartament of Genetics and Biotechnology, Saint-Petersburg State University

Aleksandra Mikhaylovna Kondrashkina

Saint-Petersburg State University

Email: alex_sandra2502@mail.ru
Student, Deptartament of Genetics and Biotechnology

Kirill Sergeyevich Antonets

Saint-Petersburg State University

Email: kir_ant@mail.ru
Student, Deptartament of Genetics and Biotechnology

Aleksey Petrovich Galkin

St. Petersburg Branch of Vavilov Institute of General Genetics (Russian Academy of Science)

Email: apgalkin@mail.ru
PhD. Head of Laboratory for Genetic Modeling of the Human and Mammalian Disorders, Vice-Director

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Copyright (c) 2013 Nizhnikov A.A., Kondrashkina A.M., Antonets K.S., Galkin A.P.

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