GENETICS AND EPIGENETICS OF AGING AND LONGEVITY

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Abstract

This review covers the main groups of genes that determine the rate of aging and longevity in model animals and humans. The focus is on genes of insulin/IGF-1, PI3K-, TOR-, MAPK-, NF-kB-, TGF-β-, WNT-signaling pathways, stress resistance genes (chaperones, antioxidant genes, autophagy, proteasomal degradation, DNA repair) and genes of cellular senescence (pRB, p21, p16, p53). The groups of genes that alter their activity during human aging and epigenetic mechanisms of age-related changes are described

About the authors

Aleksey Aleksandrovich Moskalev

Institute of biology of Komi Science Center of Ural division of RAS

Email: amoskalev@list.ru
Doctor of Biological Sciences, Head the laboratory of genetics of aging and life interval

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