Vol 4, No 3 (2013)
- Year: 2013
- Articles: 9
- URL: https://journals.rcsi.science/clinpractice/issue/view/503
Articles
THE EFFECTIVENESS OF SPHEROGEL IN THE TREATMENT OF KNEE OSTEOARTHRITIS
Abstract
The resuts of randomized, double-blind, placebo-controlled, prospective trial in parallel groups of evaluation the efficiency safety and tolerability threefold (once a week) intraarticular injection of Spherogel are discussed in the study. It is estimated of positive effect of this medication to simptoms of gonarthritis: reducing of pain and improvement of functional activity of joint with a good tolerability. This effect continuos for least 3 month.
Journal of Clinical Practice. 2013;4(3):4-10
4-10
CHARACTRISTICS OF CYTOKINES, PHENOTIPIC FEATURES AND NEUTROPHILSPHAGOCYTOSIS ACTIVITY IN ASTHMATIC PATIENTS DURING EXACERBATION
Abstract
The aim of our study was to measure the level of IL -8, IL-6, IL-4, IL-17 depending on spontaneous or induced release by peripheral blood leukocytes in patients with bronchial asthma exacerbation with comparative analysis of asthmatics' blood neutrophils phenotypic features. The obtained data indicate that the level either pro-inflammatory or anti-inflammatory cytokines was increased in patients with asthma exacerbations and significant increase of concentration of CD45+CD66b+CD11b+ cells in comparing with healthy donors. We determined that during asthma exacerbation the concentration of CD45+, CD66b+, CD11b+ blood granulocytes almost doubled in comparing with healthy donors. Also there is a significant increasing of blood granulocytes' phagocytosis activity. We observed the elevated level of spontaneous production of inflammatory mediators. Moreover, the stimulation of cytokines synthesis and release in patients with asthma does not always lead to increase of induced level of cytokines in contrast to healthy donors.
Journal of Clinical Practice. 2013;4(3):11-19
11-19
TRANSPLANTATION OF GENETIC MODIFIED STEM CELLS OVEREXPRESSING THERAPEUTIC GROWTH FACTORSFOR THE TREATMENT OF EXPERIMENTAL RAT MYOCARDIAL INFARCTION
Abstract
We tested the hypothesis that simultaneous transgenic overexpression of a select quartet of growth factors activates diverse signaling pathways for mobilization and participation of various stem/progenitor cells for cardiogenesis in the infarcted heart. IGF-1, VEGF, SDF-1α, and HGF plasmids were synthesized and transfected into rat skeletal myoblasts (SM). Overexpression of growth factors in transfected SM (TransSM) was confirmed by reverse transcription PCR, western blotting, and fluorescence immunostaining. The conditioned medium (CM) from TransSM was cytoprotective for cardiomyocytes following H 2O 2 treatment, promoted a higher transwell migration of HUVEC cells and in vitro tube formation. Intramyocardial transplantation of 1.5×10 6 TransSM in a rat model of acute myocardial infarction induced extensive mobilization of stem/progenitor cells into the infarcted heart on day 7 and improved integration of TransSM in the heart compared to NatSM. Extensive neomyogenesis and angiogenesis with resultant attenuation of infarct size and improvement in global heart function was observed at 8 weeks. In conclusion, simultaneous activation of diverse signaling pathways by overexpression of multiple growth factors caused massive mobilization and homing of stem/progenitor cells from peripheral circulation, the bone marrow, and the heart for accelerated repair of the infarcted myocardium.
Journal of Clinical Practice. 2013;4(3):20-35
20-35
CASE HYSTORY OF EARLY DIAGNOSTIC OF CHOLANGIOCARCINOMA IN PATIENTWITH CHRONIC PSEUDOTUMOR-LIKE PANCREATITIS USING THE CONFOCAL LASER ENDOMICROSCOPY
Abstract
It is described the clinical case of a rare disease – cholangiocarcinoma of the common bile duct, which developed in patient with chronic pseudotumor-like pancreatitis. It is reflected the complexity of diagnosis at an early stage of the disease. The method of confocal laser endomicroscopy was for the first time applied for the given pathology for diagnostic purposes that allowed to clarify and verify the diagnosis. The authors suggest that in diseases of the pancreato-biliary zone the method of confocal laser endomicroscopy can be crucial in cases of inefficiency or uninformativeness of other methods.
Journal of Clinical Practice. 2013;4(3):36-43
36-43
RECURRENCE OF TACHYCARDIA IN 8 YEARS AFTER RADIOFREQUENCY CATHETER ABLATIONOF SLOW PATHWAY OF ATRIOVENTRICULAR JUNCTION
Abstract
In the article the clinical case of recurrence of typical atrioventricular nodal reentry tachycardia (AVNRT) in 8 years from the moment of a radiofrequency catheter ablation of slow pathway of atrioventricular junction concerning paroxysmal AVNRT at the patient of 42 years is described.
Journal of Clinical Practice. 2013;4(3):44-48
44-48
CLINICAL ASPECTS OF TREATMENT OF PATIENTS WITH LONG-PERSISTENT FORMOF ATRIAL FIBRILLATION AND DECOMPENSATED CHRONIC HEART FAILURE, USING A METHODOF RADIOFREQUENCY CATHETER ABLATION AND CARDIAC RESYNCHRONIZATION THERAPY
Abstract
The article describes a clinical case of a 64-years patient with long-lasting persistent atrial fibrillation with the progressive course of chronic heart failure, which successfully treated with CRT setting and RFA of AFib. Dynamic observation of the patient during 12 months confirmed the success of combined treatment – absence of arrhythmia recurrences and decreasing of NYHA heart failure functional class.
Journal of Clinical Practice. 2013;4(3):49-55
49-55
56-60
PROBLEMS OF DIFFERENTIAL DIAGNOSIS OF BRONCHIOLOALVEOLAR CARCINOMA
Abstract
The review presents the modern view on bronchioloalveolar carcinoma. The most attention is paid to the CT as one of the most important methods of primary diagnosis. Authors showed distinctive features of diseases that have similar X-ray picture.
Journal of Clinical Practice. 2013;4(3):61-72
61-72
PRE-OPERATIVE THERAPEUTIC PREPARATION FOR PATIENTS IN ONCOSURGERY
Abstract
The paper deals with current possibilities of pre-operative therapeutic assessment and the management of patients with concurrent cancer and cardiac diseases.Adequate diagnostics, modern surgery and therapeutic methods in pre- and postoperative period allow to survive 12 months without features of both diseases in 68.4% of patients. 3-5 year survival rate is respectively 25.8-12.9%.
Journal of Clinical Practice. 2013;4(3):73-79
73-79