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Post a Comment CHARACTRISTICS OF CYTOKINES, PHENOTIPIC FEATURES AND NEUTROPHILSPHAGOCYTOSIS ACTIVITY IN ASTHMATIC PATIENTS DURING EXACERBATION
- Authors: Borisova TV1, Sokurenko SI1, Karaulov AV2
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Affiliations:
- ФГБУ ФНКЦ ФМБА России
- Первый МГМУ им. И.М. Сеченова
- Issue: Vol 4, No 3 (2013)
- Pages: 11-19
- Section: Articles
- URL: https://journals.rcsi.science/clinpractice/article/view/8260
- DOI: https://doi.org/10.17816/clinpract4311-19
- ID: 8260
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Abstract
The aim of our study was to measure the level of IL -8, IL-6, IL-4, IL-17 depending on spontaneous or induced release by peripheral blood leukocytes in patients with bronchial asthma exacerbation with comparative analysis of asthmatics' blood neutrophils phenotypic features. The obtained data indicate that the level either pro-inflammatory or anti-inflammatory cytokines was increased in patients with asthma exacerbations and significant increase of concentration of CD45+CD66b+CD11b+ cells in comparing with healthy donors. We determined that during asthma exacerbation the concentration of CD45+, CD66b+, CD11b+ blood granulocytes almost doubled in comparing with healthy donors. Also there is a significant increasing of blood granulocytes' phagocytosis activity. We observed the elevated level of spontaneous production of inflammatory mediators. Moreover, the stimulation of cytokines synthesis and release in patients with asthma does not always lead to increase of induced level of cytokines in contrast to healthy donors.
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##article.viewOnOriginalSite##About the authors
T V Borisova
ФГБУ ФНКЦ ФМБА России
Email: vasilchikova12@yandex.ru
врач аллерголог-иммунолог ФГБУ ФНКЦ ФМБА России
S I Sokurenko
ФГБУ ФНКЦ ФМБА России
Email: doctsok@yandex.ru
заведующий отделением аллергологии и иммунологии ФГБУ ФНКЦ ФМБА России, д.м.н., профессор.
A V Karaulov
Первый МГМУ им. И.М. Сеченова
Email: drkaraulov@mail.ru
заведующий кафедрой клинической иммунологии и аллергологии Первого МГМУ им. И.М. Сеченова, д.м.н., профессор, член-корр РАМН
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