Modern technologies of diagnosis and treatment of patient with alveolar proteinosis


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Abstract

The case of a rare lung disease - alveolar proteinosis diagnosed with advanced technologies, including confocal laser endomicroscopy of respiratory tract (alveoscopy) is presented. After confirming the diagnosis the patient undewent high volume bronchoalveolar lavage of both lungs with positive clinical and radiologic dynamics.

About the authors

Anna G. Sotnikova

Federal Scientific and Clinical Center for Specialized Types of Medical Care and Medical Technologies FMBA of Russia

Author for correspondence.
Email: sotnikoffaa@rambler.ru

doctor of the pulmonology department

Russian Federation, Moscow

Alexander V. Averyanov

Federal Scientific and Clinical Center for Specialized Types of Medical Care and Medical Technologies FMBA of Russia

Email: averyanovav@mail.ru

Deputy General Director for Research and Medical Technologies, Doctor of Medical Sciences

Russian Federation, Moscow

Tamara A. Turusina

Federal Scientific and Clinical Center for Specialized Types of Medical Care and Medical Technologies FMBA of Russia

Email: turusina@rambler.ru

Head of the Department of Pulmonology

Russian Federation, Moscow

Victor N. Lesnyak

Federal Scientific and Clinical Center for Specialized Types of Medical Care and Medical Technologies FMBA of Russia

Email: info@eco-vector.com

head Department of Radiology, Candidate of Medical Sciences

Russian Federation, Moscow

Dmitry V. Sazonov

Federal Scientific and Clinical Center for Specialized Types of Medical Care and Medical Technologies FMBA of Russia

Email: info@eco-vector.com

Head of the Endoscopy Department, Candidate of Medical Sciences

Russian Federation, Moscow

Olesya V. Danilevskaya

Federal Scientific and Clinical Center for Specialized Types of Medical Care and Medical Technologies FMBA of Russia

Email: danless@mail.ru

Doctor of the Endoscopy Department, Candidate of Medical Sciences

Russian Federation, Moscow

Andrey L. Chernyaev

Federal Scientific and Clinical Center for Specialized Types of Medical Care and Medical Technologies FMBA of Russia

Email: info@eco-vector.com

head Department of Pathology, Research Institute of Pulmonology, FMBA of Russia, Doctor of Medical Sciences, Professor

Russian Federation, Moscow

References

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  2. Borie R., Danel С., Debray М.Р. et al. Pulmonary alveolar proteinosis. Eur Respir Rev 2011; 20: 98-107
  3. А.Л. Черняев, M.B. Самсонова. Атлас «Патологическая анатомия лёгких». 2004 г.
  4. Г.Е. Труфанов, Г.М.Митусова. «Лучевая диагностика заболеваний и повреждений органов грудной полости». 2008 г.
  5. Michaud G., Reddy С., Ernst A. Whole-lung lavage for pulmonary alveolar proteinosis. Chest 2009; 136: 1678-1681
  6. Venkateshiah S.B., Yan T.D., Bonfield T.L., et al. An open-label trial of granulocyte macrophage colony stimulating factor therapy for moderate symptomatic pulmonary alveolar proteinosis. Chest 2006; 130: 227-237
  7. Salatin M., Roussel E., Hauss P.A. et al L. In vivo imaging of pulmonary alveolar proteinosis using confocal endomicroscopy Eur Respir J. 2010 Aug;36(2):451-3

Supplementary files

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2. Fig. 1. Histological preparation of the lung with alveolar proteinosis - staining with Schiff's reagent.

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3. Fig. 2. Plain chest x-ray of a patient with alveolar proteinosis.

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4. Fig. 3. Fragment of a computed tomogram of a patient with alveolar proteinosis.

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5. Fig. 4. Fragments of a computed tomogram of patient B.

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6. Fig. 5. A fragment of the lung tissue of patient B., obtained with TBLD.

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7. Fig. 6 a, b: Apveoscopy of patient B. before treatment.

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8. Fig. 7. Bronchoalveolar lavage for the patient

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9. Fig. 8. Servings of lavage liquid

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10. Fig. 9 a, b.

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11. Fig. 10 a, b.

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Copyright (c) 2021 Sotnikova A.G., Averyanov A.V., Turusina T.A., Lesnyak V.N., Sazonov D.V., Danilevskaya O.V., Chernyaev A.L.

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This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

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