DIFFICULTIES OF DIFFERENTIAL DIAGNOSIS BETWEEN ATYPICAL LEIOMYOMA AND LEIOMYOSARCOMA OF THE UTERINE BODY

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Abstract

Leiomyoma of the uterus is a benign hormone-dependent tumors in women.The incidence of LM among gynecological diseases is 25 to 50%, according to different authors. In reproductive-aged women its frequency is about 30%. WHO recommends to allocate leiomyoma, which in russian literature often referred to as a simple or ordinary leiomyoma, and its histologic variants (cellular, mitotic activity, epithelioid, myxoid, atypical leiomyoma and lipoleyomioma etc.).We performed clinical and morphological analysis of atypical uterine leiomyoma in 44-year-old woman. Immunohistochemical study detected positive reaction to smooth muscle actin, dismin, progesterone receptors, N-caldesmon. Adverse reactions to c-kit, ER keratins. Proliferation index by Ki-67 does not exceed 10%. At the molecular genetic research in the studied loci, the microsatellite instability and loss of heterozygosity, characteristic of the LMS, were not revealed.

About the authors

E A Kogan

ГБОУ ВПО Первый МГМУ им. И.М. Сеченова

M A Solomakhina

ГБОУ ВПО Первый МГМУ им. И.М. Сеченова

к.м.н., доцент кафедры патологической анатомии им А.И. Струкова Первого МГМУ им И.М. Сеченова

S I Askolskaya

ФГБУ ФНКЦ ФМБА России

Yu V Popov

ФГБУ ФНКЦ ФМБА России

A V Kozachenko

ФГБУ «Научный центр акушерства, гинекологии и перинатологии им. В.И. Кулакова» МЗ РФ

N M Fayzullina

ФГБУ «Научный центр акушерства, гинекологии и перинатологии им. В.И. Кулакова» МЗ РФ

T V Kekeeva

ФГБУ Медико-генетический научный центр РАМН

A A Shikeeva

ГБОУ ДПО РМАПО Минздрава России

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Copyright (c) 2016 Kogan E.A., Solomakhina M.A., Askolskaya S.I., Popov Y.V., Kozachenko A.V., Fayzullina N.M., Kekeeva T.V., Shikeeva A.A.

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