A clinical case of successful application of a new treatment method for severe COVID-19

Cover Page

Cite item

Full Text

Abstract

COVID-19, formerly coronavirus infection 2019-nCoV, is a potentially severe acute respiratory infection caused by the SARS-CoV-2 coronavirus (2019-nCoV). It is a dangerous disease that can occur both in the form of a mild acute respiratory viral infection and in a severe form with the development of bilateral polysegmental viral pneumonia, specific complications of which may include acute respiratory distress syndrome, resulting in the respiratory failure with a high risk of death. Due to the absence of etiotropic therapy for the coronavirus infection, pathogentic treatment becomes of primary importance. We present a clinical case of a severe form of COVID-19 in a 33-year-old man to whom we administered a new method of pathogenetic treatment of this disease based on immunosuppresiive therapy followed by therapeutic plasma exchange and infusion of non-specific human immunoglobulin.

About the authors

Alexander S. Samoylov

State Research Center — Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency

Email: asamoilov@fmbcfmba.ru
ORCID iD: 0000-0002-9241-7238
SPIN-code: 3771-4848

Corresponding Member of RAS, M.D., Professor

Russian Federation, Moscow

Yuri D. Udalov

State Research Center — Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency

Email: udalov@fmbafmbc.ru
ORCID iD: 0000-0002-9739-8478
SPIN-code: 7016-7538

M.D.

Russian Federation, Moscow

Nikolai M. Kruglyakov

State Research Center — Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency

Email: nik160@mail.ru
ORCID iD: 0000-0001-5011-6288
SPIN-code: 5763-0498
Russian Federation, Moscow

Dmitry А. Terekhov

State Research Center — Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency

Email: terexov-d@mail.ru
Russian Federation, Moscow

German I. Bagzhanov

State Research Center — Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency

Email: 1380-1410@mail.ru
ORCID iD: 0000-0003-3363-5195
SPIN-code: 8981-3430
Russian Federation, Moscow

Sergey S. Ochkin

State Research Center — Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency

Author for correspondence.
Email: Gazme@yandex.ru
ORCID iD: 0000-0001-8103-4963
SPIN-code: 2071-7804
Russian Federation, Moscow

References

  1. ВОЗ. Клиническое руководство по ведению пациентов с тяжелой острой респираторной инфекцией при подозрении на инфицирование новым коронавирусом (2019-nCoV). Временное руководство от 28 января 2020 г. WHO/nCoV/Clinical/2020.2 [интернет]. [Clinical management of severe acute respiratory infection when novel coronavirus (2019-nCoV) infection is suspected. Interim guidance 28 January 2020. WHO/nCoV/Clinical/2020.2 [Internet]. (In Russ).] Доступно по: https://webmaster.yandex.ru/siteinfo/?site=www.rospotrebnadzor.ru. Ссылка активна на 16.05.2020.
  2. Роспотребнадзор. Рекомендации ВОЗ для населения в связи c распространением нового коронавируса (2019-nCoV): мифы и ложные представления [интернет]. [Rospotrebnadzor. Rekomendatsii VOZ dlya naseleniya v svyazi c rasprostraneniyem novogo koronavirusa (2019-nCoV): mify i lozhnyye predstavleniya [Internet]. (In Russ).] Доступно по: https://www.rospotrebnadzor.ru/region/rss/rss.php?ELEMENT_ID=13990. Ссылка активна на 16.05.2020.
  3. Bassetti M, Vena A, Giacobbe DR. The novel chinese coronavirus (2019-nCoV) infections: challenges for fighting the storm. Eur J Clin Invest. 2020;50(3):e13209. doi: 10.1111/eci.13209.
  4. Beeching, Fletcher, Fowler, 2020, Prognosis, Case fatality rate. Available from: https://www.semanticscholar.org/paper/The-novel-Chinese-coronavirus-(2019-nCoV)-for-the-Bassetti-Vena/d3373cd7db828a91a2709ea8fbec7d6776b6f42f
  5. Mandell LA, Wunderink RG, Anzueto A, et al. Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis. 2007;44(Suppl 2):S27–72. doi: 10.1086/511159.
  6. Faqihi F, Alharthy A, Alodat M, et al. A pilot study of therapeutic plasma exchange for serious SARS CoV-2 disease (COVID-19): A structured summary of a randomized controlled trial study protocol. Trials. 2020;21:506. doi: 10.1186/s13063-020-04454-4.
  7. Hua Shi, Chaomin Zhou, Pinghong He, et al. . Successful treatment of plasma exchange followed by intravenous immunogloblin in a critically ill patient with 2019 novel coronavirus infection. Int J Antimicrob Agents. 2020;105974. doi: 10.1016/j.ijantimicag.2020.105974.
  8. Gorbalenya AE, Baker SC, Baric RS, et al. Severe acute respiratory syndrome-related coronavirus: The species and its viruses — a statement of the Coronavirus Study Group. bioRxiv. 2020. doi: 10.1101/2020.02.07.937862.
  9. Lu H. Drug treatment options for the 2019-new coronavirus (2019-nCoV). Biosci Trends. 2020;14(1):69–71. doi: 10.5582/bst.2020.01020.
  10. Zhang J, Zhou L, Yang Yu, et al. Therapeutic and triage strategies for 2019 novel coronavirus disease in fever clinics. Lancet Respir Med. 2020;8(3):e11–e12. doi: 10.1016/S2213-2600(20)30071-0.
  11. Chang L, Yan Y, Wang L. Coronavirus disease 2019: coronaviruses and blood safety. Transfus Med Rev. 2020;34(2):75–80. doi: 10.1016/j.tmrv.2020.02.003.
  12. Распоряжение Правительства РФ от 12 октября 2019 г. № 2406-р. [Order of the Government of the Russian Federation № 2406-r dated 2019 October 12. (In Russ).] Доступно по: https://www.garant.ru/products/ipo/prime/doc/72761778/. Ссылка активна на 20.04.2020.
  13. Диагностика и интенсивная терапия острого респираторного дистресс-синдрома. (In Russ).] Доступно по: http://www.far.org.ru/recomendation

Supplementary files

Supplementary Files
Action
1. JATS XML
Download
2. Fig. 1. Computed tomography of the lungs from 04.24.2020: an increase in the prevalence and intensity of pathological changes with subtotal lesions of the pulmonary parenchyma, CT4

Download (200KB)
Indexing metadata
3. Fig. 2. Computed tomography of the lungs from 04/29/2020: against the background of improving the condition of the lung tissue, the development of right-sided lower lobe bronchopneumonia is noted

Download (162KB)
Indexing metadata
4. Fig. 3. Computed tomography of the lungs 05/02/2020: positive dynamics during treatment

Download (181KB)
Indexing metadata

Copyright (c) 2020 Samoylov A.S., Udalov Y.D., Kruglyakov N.M., Terekhov D.А., Bagzhanov G.I., Ochkin S.S.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies