Сontribution of circadian rhythms to the development of neurological disorders after prolonged anesthesia

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Abstract

Despite the improvement of pre-, intra- and postoperative care methods, the problem of the development of postoperative neurological complications following prolonged anesthesia remains. A mechanism of occurrence of these complications may be circadian rhythm disorders. This article presents a review of the literature data on the prevalence, pathophysiological mechanisms, and risk factors of postoperative autonomic and circadian disorders. Notably, circadian rhythm disorders in surgical patients are observed at several levels: disruption of the sleep and wakefulness cycle, decreased melatonin secretion, instability of cortisol levels and body temperature, and changes in the vegetative balance towards sympathetic regulation. These disorders contribute to the development of postoperative pain and cognitive and anxiety-depressive disorders, hinder effective rehabilitation, and may be associated with postoperative mortality.

About the authors

Nikita A. Mazurov

Tyumen State Medical University

Author for correspondence.
Email: nikita_banzay@mail.ru
ORCID iD: 0009-0002-7289-4587
SPIN-code: 3824-0682
Russian Federation, Tyumen

Oksana A. Kicherova

Tyumen State Medical University

Email: pan1912@mail.ru
ORCID iD: 0000-0002-7598-7757
SPIN-code: 3162-0770

MD, PhD, Associate Professor

Russian Federation, Tyumen

Tatyana E. Verbakh

Tyumen State Medical University

Email: shtork@yandex.ru
ORCID iD: 0000-0002-6294-1776
SPIN-code: 7776-4134

MD, PhD

Russian Federation, Tyumen

Lyudmila I. Reichert

Tyumen State Medical University

Email: lir0806@gmail.com
ORCID iD: 0000-0003-4313-0836
SPIN-code: 1703-2302

MD, PhD, Professor

Russian Federation, Tyumen

Yulia I. Doyan

Tyumen State Medical University

Email: yul-gol25@yandex.ru
ORCID iD: 0000-0002-8486-496X
SPIN-code: 2748-9442

MD, PhD

Russian Federation, Tyumen

Valentina A. Saltanova

Tyumen State Medical University

Email: valentinaslt72@gmail.com
ORCID iD: 0009-0002-1304-2202
Russian Federation, Tyumen

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