Вклад циркадных ритмов в развитие неврологических нарушений после длительного анестезиологического обеспечения

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Несмотря на совершенствование методов до-, интра- и послеоперационного ухода, сохраняется проблема послеоперационных неврологических осложнений после длительного анестезиологического пособия. Одним из механизмов возникновения указанных осложнений могут быть нарушения циркадного ритма. Авторами представлен обзор литературных данных о распространённости, патофизиологических механизмах и факторах риска послеоперационных вегетативных и циркадных нарушений. Установлено, что нарушения циркадного ритма у хирургических больных наблюдаются на нескольких уровнях: нарушение цикла сна и бодрствования, снижение секреции мелатонина, нестабильность уровня кортизола и температуры тела, а также изменение вегетативного баланса в сторону симпатической регуляции. Указанные нарушения способствуют развитию постоперационной боли, неврологических, когнитивных и тревожно-депрессивных нарушений, препятствуют эффективной реабилитации и могут быть связаны с послеоперационной смертностью.

Об авторах

Никита Александрович Мазуров

Тюменский государственный медицинский университет

Автор, ответственный за переписку.
Email: nikita_banzay@mail.ru
ORCID iD: 0009-0002-7289-4587
SPIN-код: 3824-0682
Россия, Тюмень

Оксана Альбертовна Кичерова

Тюменский государственный медицинский университет

Email: pan1912@mail.ru
ORCID iD: 0000-0002-7598-7757
SPIN-код: 3162-0770

д-р мед. наук, доцент

Россия, Тюмень

Татьяна Эдуардовна Вербах

Тюменский государственный медицинский университет

Email: shtork@yandex.ru
ORCID iD: 0000-0002-6294-1776
SPIN-код: 7776-4134

канд. мед. наук

Россия, Тюмень

Людмила Ивановна Рейхерт

Тюменский государственный медицинский университет

Email: lir0806@gmail.com
ORCID iD: 0000-0003-4313-0836
SPIN-код: 1703-2302

д-р мед. наук, профессор

Россия, Тюмень

Юлия Ивановна Доян

Тюменский государственный медицинский университет

Email: yul-gol25@yandex.ru
ORCID iD: 0000-0002-8486-496X
SPIN-код: 2748-9442

канд. мед. наук

Россия, Тюмень

Валентина Анатольевна Салтанова

Тюменский государственный медицинский университет

Email: valentinaslt72@gmail.com
ORCID iD: 0009-0002-1304-2202
Россия, Тюмень

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