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Post a Comment Association of the AGT, ACE, NOS3 polymorphism with subclinical arterial wall changes and cardiovascular diseases risk factors
- Authors: Akopyan A.A.1,2, Kirillova K.I.1, Strazhesko I.D.1,2, Samokhodskaya L.M.1, Leonov S.L.3, Gelfand E.M.3, Sorokina A.G.1, Orlova I.A.1
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Affiliations:
- Medical Scientific and Educational Center of Lomonosov Moscow State University
- Russian Gerontology Research Center of Pirogov Russian National Research Medical University
- Polzunov Altai State Technical University
- Issue: Vol 11, No 1 (2020)
- Pages: 30-41
- Section: Basic Science
- URL: https://journals.rcsi.science/clinpractice/article/view/18572
- DOI: https://doi.org/10.17816/clinpract18572
- ID: 18572
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Abstract
Background. Renin-Angiotensin-Aldosterone System activation (RAAS) and nitric oxide (NO) reduction lead to the changes in the arterial wall, which, in turn, create a favourable environment for the development of cardiovascular diseases (CVD). There is only limited knowledge of the influence of proteins participating in the RAAS activation and providing NO bioavailability on the parameters of the arterial wall state (pulse wave velocity (PWV), carotid artery intima-media thickness (cIMT), endothelium-dependent vasodilation (EDVD), presence of atherosclerotic plaques) and risk factors of CVD.
Aim. Finding the association between the AGT, ACE, NOS3 polymorphism and PWV, cIMT, EDV, presence of atherosclerotic plaques and risk factors of CVD in healthy subjects.
Methods. Using intergroup analysis and models of multiple logistic regression, we examined the association of AGT с.521С>Т polymorphism, AСE Ins>Del polymorphism, NOS3 с.894G>T polymorphism with arterial wall changes and risk factors of CVD in 160 healthy people of different ages.
Results. The CT genotype of AGT с.521С>Т polymorphism was associated with lower levels of systolic blood pressure (BP) (p=0.013) and central systolic BP (p=0.029), higher level of Insulin-Like Growth Factor (IGF) (p=0.027). The DD genotype of ACE Ins>Del polymorphism was associated with a higher waist/hip ratio (p=0.044), lower level of high density lipoprotein cholesterol (p=0.01), lower index of EDVD (p=0.042), higher incidence ofendothelial dysfunction (ED) (p=0.026). The GG genotype of NOS3 с.894G>T polymorphism was associated with higher levels of central systolic BP (p=0.022) and central mean BP (p=0.033), total cholesterol (p=0.025), low density lipoprotein cholesterol (p=0.014) and IGF (p=0.042), higher incidence of ED (p=0.007), albuminuria (p=0.032) and insulin resistance (p=0.03).
Conclusion. We have found the association of the AСE and NOS3 polymorphism with endothelial dysfunction and the metabolic status.
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##article.viewOnOriginalSite##About the authors
A. A. Akopyan
Medical Scientific and Educational Center of Lomonosov Moscow State University; Russian Gerontology Research Center of Pirogov Russian National Research Medical University
Author for correspondence.
Email: a.alexandrova18@gmail.com
ORCID iD: 0000-0002-2362-9798
SPIN-code: 4841-2901
MD, Research intern at the Department of Age-related diseases; Junior Researcher of the Laboratory of Translational medicine
Russian Federation, MoscowK. I. Kirillova
Medical Scientific and Educational Center of Lomonosov Moscow State University
Email: dkkirillova@gmail.com
ORCID iD: 0000-0002-0873-7387
SPIN-code: 4440-1859
ResearcherId: AAE-4599-2019
MD,Researcher at Medical Laboratory Department
Russian Federation, MoscowI. D. Strazhesko
Medical Scientific and Educational Center of Lomonosov Moscow State University; Russian Gerontology Research Center of Pirogov Russian National Research Medical University
Email: istrazhesko@gmail.com
SPIN-code: 9049-7884
ResearcherId: AAD-9390-2019
Leading Researcher at the Department of Age-related diseases; MD, PhD, Deputy Director of translational medicine
Russian Federation, MoscowL. M. Samokhodskaya
Medical Scientific and Educational Center of Lomonosov Moscow State University
Email: SLM@fbm.msu.ru
SPIN-code: 9049-7884
MD,PhD, Associate Professor, Head of Medical Laboratory Department, Medical Scientific and Educational Center
Russian Federation, MoscowS. L. Leonov
Polzunov Altai State Technical University
Email: sergey_and_nady@mail.ru
PhD, Professor, Professor at the Department of manufacturing engineering
Russian Federation, BarnaulE. M. Gelfand
Polzunov Altai State Technical University
Email: gelfand.el@gmail.com
ORCID iD: 0000-0001-5646-9324
SPIN-code: 6624-3640
PhD, Associate Professor, Associate Professor at the Department of higher mathematics
Russian Federation, BarnaulA. G. Sorokina
Medical Scientific and Educational Center of Lomonosov Moscow State University
Email: drsorokinaag@gmail.com
ORCID iD: 0000-0003-2310-936X
SPIN-code: 2051-0379
MD,Researcher at the Department of Age-related diseases, Medical Scientific and Educational Center
Russian Federation, MoscowI. A. Orlova
Medical Scientific and Educational Center of Lomonosov Moscow State University
Email: 5163002@bk.ru
ORCID iD: 0000-0002-8160-5612
SPIN-code: 3153-8373
MD, PhD, Professor, Head of the Department of Age-related diseases, Medical Scientific and Educational Center
Russian Federation, MoscowReferences
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