Magnetic resonanse imaging as a prognostic tool in encephalitis in children

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Abstract

We provide the data on the modern use of MRI of different modalities as a prognostic tool in the encephalitis diagnostics in pediatrics. According to the recent scientific knowledge, this implementation is possible, but its efficacy depends on the modality of MRI: structural, functional or MRI with contrast. Structural MRI efficacy in children with encephalitis is dubious and clearly depends on the etiology and phase of the inflammatory process. In the recent years, the implementation of the functional MRI methods (DTI & MRS) and MRI with contrast significantly changed the imaging practice; there are some reports that these modalities of MRI are more effective as a prognostic tool in encephalitis than the structural one. Thus, a future research in this field is needed.

About the authors

Natalia V. Marchenko

Pediatric Research and Clinical Center for Infectious Diseases

Email: gmv@mail.ru

MD, PhD, Head of the department

Russian Federation, St-Petersburg

Vladislav B. Voitenkov

Pediatric Research and Clinical Center for Infectious Diseases; Academy of Postgraduate Education under the FSBU «Federal Scientific and Clinical Center for Specialized Medical Assistance and Medical Technologies of the Federal Medical Biological Agency»

Author for correspondence.
Email: vlad203@inbox.ru
ORCID iD: 0000-0003-0448-7402

MD, PhD, Head of the department, Associate Professor

Russian Federation, St-Petersburg; Moscow

Natalia V. Skripchenko

Pediatric Research and Clinical Center for Infectious Diseases

Email: snv@niidi.ru

MD, PhD,  Dr.Hab, Professor, Deputy Director

Russian Federation, St-Petersburg

Olga O. Kurzanceva

Academy of Postgraduate Education under the FSBU «Federal Scientific and Clinical Center for Specialized Medical Assistance and Medical Technologies of the Federal Medical Biological Agency»

Email: science@medprofedu.ru

канд. мед. наук, доцент, ученый секретарь Ученого совета

Russian Federation, Moscow

References

  1. Лобзин Ю.В., Рычкова С.В., Скрипченко Н.В., и др. Состояние инфекционной заболеваемости у детей в Российской Федерации за 2016–2017 гг. // Медицина экстремальных ситуаций. — 2018. — Т.20. — №3. — С. 253–261. [Lobzin YuV, Rychkova SV, Skripchenko NV, et al. The state of infectious disease prevalence rate in children in the russian federation for the period of 2016–2017. Medicina jekstremal’nyh situacij. 2018;20(3):253–261. (In Russ).]
  2. Коновалов А.Н., Корниенко В.Н., Пронин И.Н. Магнитно-резонансная томография в нейрохирургии. — М.: ТОО «Видар»; 1997. — 471 с. [Konovalov AN, Kornienko VN, Pronin IN. Magnitno-rezonansnaja tomografija v nejrohirurgii. Moscow: TOO «Vidar»; 1997. 471 р. (In Russ).]
  3. Трофимова Т.Н., Ананьева Н.И., Назинкина Ю.В., и др. Нейрорадиология. — СПб.; 2009. — 288 с. [Trofimova TN, Anan’eva NI, Nazinkina JuV, i dr. Nejroradiologija. Saint Petersburg; 2009. 288 р. (In Russ).]
  4. Hanning U, Roesler A, Peters A, et al. Structural brain changes and all-cause mortality in the elderly population-the mediating role of inflammation. Age (Dordr). 2016;38(5-6):455–464. doi: 10.1007/s11357-016-9951-9.
  5. Rao S, Elkon B, Flett KB, et al. Long-term outcomes and risk factors associated with acute encephalitis in children. J Pediatric Infect Dis Soc. 2017;6(1):20–27. doi: 10.1093/jpids/piv075.
  6. Dong X, Zheng D, Nao J. Clinical characteristics and factors associated with short-term prognosis in adult patients with autoimmune encephalitis of non-neoplastic etiology. Neurol Sci. 2019;40(8):1567–1575. doi: 10.1007/s10072-019-03883-7.
  7. Wang GL, Yin F, Wang Y. [Clinical analysis of 71 cases of anti-N-methyl-D-aspartate receptor encephalitis in children. (Article in Chinese).] Zhonghua Er Ke Za Zhi. 2019;57(2):125–130. doi: 10.3760/cma.j.issn.0578-1310.2019.02.012.
  8. Si Z, Wang A, Liu J. Typical clinical and imaging manifestations of encephalitis with anti-γ-aminobutyric acid B receptor antibodies: clinical experience and a literature review. Neurol Sci. 2019;40(4):769–777. doi: 10.1007/s10072-018-3679-5.
  9. Sai Y, Zhang X, Feng M, et al. Clinical diagnosis and treatment of pediatric anti-N-methyl-D-aspartate receptor encephalitis: A single center retrospective study. Exp Ther Med. 2018;16(2):1442–1448. doi: 10.3892/etm.2018.6329.
  10. Li W, Wu S, Meng Q, et al. Clinical characteristics and short-term prognosis of LGI1 antibody encephalitis: a retrospective case study. BMC Neurol. 2018;18(1):96. doi: 10.1186/s12883-018-1099-z.
  11. Broadley J, Seneviratne U, Beech P, et al. Prognosticating autoimmune encephalitis: a systematic review. J Autoimmun. 2019;96:24–34. doi: 10.1016/j.jaut.2018.10.014.
  12. Dyachenko P, Smiianova O, Kurhanskaya V, et al. Epstein-barr virus-associated encephalitis in a case-series of more than 40 patients. Wiad Lek. 2018;71(6):1224–1230.
  13. Graus F, Escudero D, Oleaga L, et al. Syndrome and outcome of antibody-negative limbic encephalitis. Eur J Neurol. 2018;25(8):1011–1016. doi: 10.1111/ene.13661.
  14. Hoepner R, Kolb EM, Dahlhaus S, et al. Predictors of severity and functional outcome in natalizumab-associated progressive multifocal leukoencephalopathy. Mult Scler. 2017;23(6):830–835. doi: 10.1177/1352458516667241.
  15. Marinelli L, Trompetto C, Cocito L. Diffusion magnetic resonance imaging diagnostic relevance in pyogenic ventriculitis with an atypical presentation: a case report. BMC Res Notes. 2014;7:149. doi: 10.1186/1756-0500-7-149.
  16. Kalita J, Mani VE, Bhoi SK, Misra UK. Spectrum and outcome of acute infectious encephalitis/encephalopathy in an intensive care unit from India. QJM. 2017;110(3):141–148. doi: 10.1093/qjmed/hcw132.
  17. Misra UK, Kalita J, Mani VE, et al. Central nervous system and muscle involvement in dengue patients: A study from a tertiary care center. J Clin Virol. 2015;72:146–151. doi: 10.1016/j.jcv.2015.08.021.
  18. Szots M, Blaabjerg M, Orsi G, et al. Global brain atrophy and metabolic dysfunction in LGI1 encephalitis: A prospective multimodal MRI study. J Neurol Sci. 2017;376:159–165. doi: 10.1016/j.jns.2017.03.020.
  19. Rao AS, Varma DR, Chalapathi Rao MV, Mohandas S. Case report: magnetic resonance imaging in rabies encephalitis. Indian J Radiol Imaging. 2009;19(4):301–304. doi: 10.4103/0971-3026.57214.
  20. Guo Y, Wang S, Jiang B, et al. Encephalitis with reversible splenial and deep cerebral white matter lesions associated with Epstein-Barr virus infection in adults. Neuropsychiatr Dis Treat. 2017;13:2085–2092. doi: 10.2147/NDT.S135510.
  21. Godi C, De Vita E, Tombetti E, et al. High b-value diffusion-weighted imaging in progressive multifocal leukoencephalopathy in HIV patients. Eur Radiol. 2017;27(9):3593–3599. doi: 10.1007/s00330-017-4761-8.
  22. Li JW, Gao XY, Wu Y, et al. A centralized report on pediatric japanese encephalitis cases from beijing children’s hospital, 2013. Biomed Environ Sci. 2016;29(12):902–908. doi: 10.3967/bes2016.121.
  23. Chen F, Li J, Liu T, et al. MRI characteristics of brainstem encephalitis in hand-foot-mouth disease induced by enterovirus type 71 — will different MRI manifestations be helpful for prognosis? Eur J Paediatr Neurol. 2013;17(5):486–491. doi: 10.1016/j.ejpn.2013.03.004.
  24. Bender A, Schulte-Altedorneburg G, Walther EU, Pfister HW. Severe tick borne encephalitis with simultaneous brain stem, bithalamic, and spinal cord involvement documented by MRI. J J Neurol Neurosurg Psychiatry. 2005;76(1):135–137.
  25. Schmolck H, Maritz E, Kletzin I, Korinthenberg R. Neurologic, neuropsychologic, and electroencephalographic findings after European tick-borne encephalitis in children. J Child Neurol. 2005;20(6):500–508. doi: 10.1177/088307380502000606.
  26. Jones N, Sperl W, Koch J, et al. Tick-borne encephalitis in a 17-day-old newborn resulting in severe neurologic impairment. Pediatr Infect Dis J. 2007 Feb;26(2):185–186.
  27. von Stülpnagel C, Winkler P, Koch J, et al. MRI-imaging and clinical findings of eleven children with tick-borne encephalitis and review of the literature. Eur J Paediatr Neurol. 2016;20(1):45–52. doi: 10.1016/j.ejpn.2015.10.008.
  28. Zawadzki R, Garkowski A, Kubas B, et al. Evaluation of imaging methods in tick-borne encephalitis. Pol J Radiol. 2017;82:742–747. doi: 10.12659/PJR.903940.
  29. Kaiser R. The clinical and epidemiological profile of tick-borne encephalitis in southern Germany 1994-98: a prospective study of 656 patients. Brain. 1999;122(Pt 11):2067–2078. doi: 10.1093/brain/122.11.2067.
  30. Lenhard T, Ott D, Jakob NJ, et al. Predictors, Neuroimaging characteristics and long-term outcome of severe european tick-borne encephalitis: a prospective cohort study. PLoS One. 2016;11(4):e0154143. doi: 10.1371/journal.pone.0154143.
  31. Singh TD, Fugate JE, Hocker S, et al. Predictors of outcome in HSV encephalitis. J Neurol. 2016;263(2):277–289. doi: 10.1007/s00415-015-7960-8.
  32. Rabinstein AA. Herpes virus encephalitis in adults: current knowledge and old myths. Neurol Clin. 2017;35(4):695–705. doi: 10.1016/j.ncl.2017.06.006.
  33. Okanishi T, Yamamoto H, Hosokawa T, et al. Diffusion-weighted MRI for early diagnosis of neonatal herpes simplex encephalitis. Brain Dev. 2015;37(4):423–431. doi: 10.1016/j.braindev.2014.07.006.
  34. Wong AM, Yeh CH, Lin JJ, et al. Arterial spin-labeling perfusion imaging of childhood encephalitis: correlation with seizure and clinical outcome. Neuroradiology. 2018;60(9):961–970. doi: 10.1007/s00234-018-2062-9.
  35. Sainz-de-la-Maza S, Casado JL, Pérez-Elías MJ, et al. Incidence and prognosis of immune reconstitution inflammatory syndrome in HIV-associated progressive multifocal leucoencephalopathy. Eur J Neurol. 2016;23(5):919–925. doi: 10.1111/ene.12963.
  36. Скрипченко Н.В., Савина М.В., Команцев В.Н., Иванова Г.П. Вирусные энцефалиты у детей: прогнозирование исходов // Детские инфекции. — 2009. — Т.8. — №2. — С. 3–5. [Skripchenko NV, Savina MV, Komancev VN, Ivanova GP. Viral encephalitis in children: рrognostication of outcomes. Detskie infekcii. 2009;8(2):3–5. (In Russ).]
  37. Скрипченко Е.Ю., Иванова Г.П., Скрипченко Н.В., и др. Клинико-лабораторная дифференциальная диагностика рассеянного склероза, диссеминированных энцефаломиелитов и энцефалитов у детей // Вестник Российской военно-медицинской академии. — 2018. —№3. — C. 158–159. [Skripchenko EJu, Ivanova GP, Skripchenko NV, et al. Kliniko-laboratornaja differencial’naja diagnostika rassejannogo skleroza, disseminirovannyh jencefalomielitov i jencefalitov u detej. Vestnik Rossijskoj voenno-medicinskoj akademii. 2018;(3):158–159. (In Russ).]
  38. Baten A, Desai M, Melo-Bicchi M, Gutierrez C. Continuous electroencephalogram as a biomarker of disease progression and severity in herpes simplex virus-1 encephalitis. Clin EEG Neurosci. 2019;50(5):361–365. doi: 10.1177/1550059419835705.
  39. Дамулин И.В., Екушева Е.В. Клиническое значение феномена нейропластичности при ишемическом инсульте // Анналы клинической и экспериментальной неврологии. — 2016. — Т.10. — №1. — С. 57–64. [Damulin IV, Ekusheva EV. A clinical value of neuroplasticity in ischemic stroke. Annaly klinicheskoj i jeksperimental’noj nevrologii. 2016;10(1):57–64. (In Russ).]
  40. Екушева Е.В., Дамулин И.В. К вопросу о межполушарной асимметрии в условиях нормы и патологии // Журнал неврологии и психиатрии им. C.C. Корсакова. — 2014. — Т.114. — №3. — С. 92–97. [Ekusheva EV, Damulin IV. The interhemispheric asymmetry in normalcy and pathology. Zhurnal nevrologii i psihiatrii im. C.C. Korsakova. 2014;114(3):92–97. (In Russ).]

Supplementary files

Supplementary Files
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1. JATS XML
2. Fig. 1. MRI of the brain of patient H., 4 years old: encephalitis of cytomegalovirus etiology, acute period of the disease

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3. Fig. 2. Brain MRI of patient H., 4 years old: encephalitis of cytomegalovirus etiology, acute period of the disease

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4. Fig. 3. Brain MRI of patient H., 4 years old: encephalitis of cytomegalovirus etiology, acute period of the disease

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5. Fig. 4. MRI of the brain of patient M., 10 years old: encephalitis of cytomegalovirus etiology

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Copyright (c) 2019 Marchenko N.V., Voitenkov V.B., Skripchenko N.V., Kurzanceva O.O.

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This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

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