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Post a Comment A pilot study to determine the relationship of changes in the characteristics of β1- and β2-adrenoreceptors against the background of the use of β2-agonists with clinically significant parameters in patients with cardiovascular pathology
- Authors: Smolyakova E.V.1,2, Skoblov Y.S.3, Skoblova N.A.3, Rvacheva A.V.1,4, Bondarets O.V.1, Eremenko A.V.1,2, Kelekhsaev I.A.1, Chazova I.E.4, Zykov K.A.1,2
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Affiliations:
- Moscow State University of Medicine and Dentistry named after A.I. Evdokimov
- Pulmonology Scientific Research Institute
- Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry
- National Medical Research Center of Cardiology
- Issue: Vol 14, No 1 (2023)
- Pages: 66-76
- Section: Original Study Articles
- URL: https://journals.rcsi.science/clinpractice/article/view/142806
- DOI: https://doi.org/10.17816/clinpract117542
- ID: 142806
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Abstract
Background: Comorbid cardiovascular and bronchoobstructive diseases worsens disease course and prognosis and causes difficulties in therapy. Effectiveness β2-agonists (cornerstone of bronchoobstructive pathology treatment) depends on β-adrenoreceptors state. Therefore, a detailed study of the functional state of beta-adrenoreceptors is necessary.
Aim: to evaluate the relationship of changes in the characteristics of β1- and β2-adrenoreceptors, against the background of the use of β2-agonists in patients with cardiovascular and bronchoobstructive diseases with clinically significant parameters.
Methods: In the pilot single-center prospective study during 2.5 years 45 patients (15 with cardiovascular and 30 with bronchoobstructive diseases) were included. Anamnestic data and complaints were collected and laboratory and instrumental studies were performed. Modified radioligand analysis on blood T-lymphocytes using radiolabeled Cyanopindolol and unlabeled selective ligands (ICI 118551, CGP 20712) before and after salbutamol and formoterol was performed and the binding activity of β1- and β2-adrenoreceptors was determined.
Results: The correlation analysis between clinically significant parameters and changes in the specific binding index of β1- and β2-adrenoreceptors confirmed its clinical relevance. In test with beta-agonists in cardiovascular and bronchoobstructive diseases patients, an increase in the specific binding index of β1-adrenoreceptors is associated with clinical, laboratory and instrumental parameters of a favorable course of the disease, and an increase in the specific binding index of β2-adrenoreceptors is associated with negative. In the cardiovascular group without bronchoobstructive diseases with salbutamol an increase in the specific binding index of β1-adrenoreceptors was associated with parameters of unfavorable disease course, while an increase in the specific binding index of β2-adrenoreceptors did not have a clear associative relationship with clinical characteristics.
Conclusions: The association of changes in the specific binding index of β1- and β2-adrenoreceptors in patients with cardiovascular and bronchoobstructive diseases with clinically significant parameters during acute tests with short- and long-acting β2-agonists was revealed, which in the future may provide an opportunity to identify patients with an unfavorable course of the disease.
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##article.viewOnOriginalSite##About the authors
Ekaterina V. Smolyakova
Moscow State University of Medicine and Dentistry named after A.I. Evdokimov; Pulmonology Scientific Research Institute
Author for correspondence.
Email: smolyakovak@mail.ru
ORCID iD: 0000-0002-1904-5319
SPIN-code: 1751-0230
MD, PhD
Russian Federation, 20/1 Delegatskaya street, 127473 Moscow; MoscowYuri S. Skoblov
Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry
Email: uskoblov@gmail.com
ORCID iD: 0000-0003-3659-3939
MD, PhD
Russian Federation, MoscowNatalia A. Skoblova
Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry
Email: uskoblov@gmail.com
ORCID iD: 0000-0002-2413-1051
инженер (изотопный блок)
Russian Federation, MoscowAnna V. Rvacheva
Moscow State University of Medicine and Dentistry named after A.I. Evdokimov; National Medical Research Center of Cardiology
Email: arvatcheva@mail.ru
ORCID iD: 0000-0001-9277-2291
SPIN-code: 5267-9598
MD, PhD
Russian Federation, 20/1 Delegatskaya street, 127473 Moscow; MoscowOlga V. Bondarets
Moscow State University of Medicine and Dentistry named after A.I. Evdokimov
Email: o.v.bondarets@gmail.com
ORCID iD: 0000-0003-1555-1449
SPIN-code: 7785-0655
MD, PhD
Russian Federation, 20/1 Delegatskaya street, 127473 MoscowAnna V. Eremenko
Moscow State University of Medicine and Dentistry named after A.I. Evdokimov; Pulmonology Scientific Research Institute
Email: a_nn87@list.ru
ORCID iD: 0000-0001-9333-0022
SPIN-code: 2813-1638
научный сотрудник лаборатории иммунологии, лаборант исследователь лаборатории пульмонологии
Russian Federation, 20/1 Delegatskaya street, 127473 Moscow; MoscowIvan A. Kelekhsaev
Moscow State University of Medicine and Dentistry named after A.I. Evdokimov
Email: kelexsaev1996@mail.ru
ORCID iD: 0000-0002-6439-4745
старший лаборант кафедры факультетской терапии и профболезней
Russian Federation, 20/1 Delegatskaya street, 127473 MoscowIrina E. Chazova
National Medical Research Center of Cardiology
Email: chazova@hotmail.ru
ORCID iD: 0000-0002-9822-4357
SPIN-code: 6175-6138
MD, PhD, Professor, Academician of the Russian Academy of Sciences
Russian Federation, MoscowKirill A. Zykov
Moscow State University of Medicine and Dentistry named after A.I. Evdokimov; Pulmonology Scientific Research Institute
Email: kirillaz@inbox.ru
ORCID iD: 0000-0003-3385-2632
SPIN-code: 6269-7990
MD, PhD, Professor, Corresponding Member of the Russian Academy of Sciences
Russian Federation, 20/1 Delegatskaya street, 127473 Moscow; MoscowReferences
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