Long QT Syndrome in Young Athletes

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Abstract

Long QT syndrome is a disease associated with a high risk of sudden cardiac (arrhythmic) death. The frequency of sudden cardiac death is approximately 1: 100,000 young athletes, while autopsies often do not detect changes, which indicates a primary arrhythmogenic death. The article describes two clinical cases of young athletes with prolongation of the QT interval. The possible causes of the long QT syndrome and the difficulties of diagnosing this syndrome in children and adolescents involved in sports are discussed. Regardless of the reasons leading to the prolongation of the QT interval, there is a risk of arrhythmic events. Timely diagnosis of long QT syndrome is the way to the primary prevention of sudden cardiac death in young athletes.

About the authors

Svetlana N. Chuprova

North-Western State Medical University named after I.I. Mechnikov; Federal State-Financed Institution Pediatric Research and Clinical Center for Infectious Diseases under the Federal Medical Biological Agency

Author for correspondence.
Email: svetlana_ch_70@mail.ru
ORCID iD: 0000-0002-5661-3389
SPIN-code: 8696-7178

Associate Professor

Russian Federation, Saint Petersburg; Saint Petersburg

Irina Yu. Melnikova

North-Western State Medical University named after I.I. Mechnikov

Email: melnikovai@yandex.ru
ORCID iD: 0000-0002-1284-5890
SPIN-code: 8053-1512

Head of the Department

Russian Federation, Saint Petersburg

References

  1. Makarov LM. Sport and sudden death in children. Russian Bulletin of Perinatology and Pediatrics. 2017;62(1):40–46. (In Russ.) doi: 10.21508/1027-4065-2017-62-1-40-46
  2. Longo UG, Ambrogioni LR, Ciuffreda M, et al. Sudden cardiac death in young athletes with long QT syndrome: the role of genetic testing and cardiovascular screening. Br Med Bull. 2018;1(127): 43–53. doi: 10.1093/bmb/ldy017
  3. Krahn AD, Laksman Z, Sy RW, et al. Congenital Long QT syndrome. JACC Clin Electrophysiol. 2022;8(5):687–706. doi: 10.1016/j.jacep.2022.02.017
  4. Schwartz PJ. Idiopathic long QT syndrome: progress and questions. Am Heart J. 1985;109(2):399–411. doi: 10.1016/0002-8703(85)90626-x
  5. Sy RW, van der Werf C, Chattha IS, et al. Derivation and validation of a simple exercise-based algorithm for prediction of genetic testing in relatives of LQTS probands. Circulation. 2011;124(20):2187–2194. doi: 10.1161/CIRCULATIONAHA.111.028258
  6. Schwartz PJ, Crotti L. QTc behavior during exercise and genetic testing for the long-QT syndrome. Circulation. 2011;124(20): 2181–2184. doi: 10.1161/CIRCULATIONAHA.111.062182
  7. Adler A, Novelli V, Amin AS, et al. An International, Multicentered, Evidence-Based Reappraisal of Genes Reported to Cause Congenital Long QT Syndrome. Circulation. 2020;141(6):418–428. doi: 10.1161/CIRCULATIONAHA.119.043132
  8. Arthur AM, Ahmad S, Pieter G Diagnosis, management and therapeutic strategies for congenital long QT syndrome. Heart. 2021;108(5):332–338. doi: 10.1136/heartjnl-2020-318259
  9. Makarov LM, Komolyatova VN, Kupriyanova OO, et al. National russian guidelines on application of the methods of holter monitoring in clinical practice. Russian Journal of Cardiology. 2014;2(106):6–71. (In Russ.). doi: 10.15829/1560-4071-2014-2-6-71
  10. Tardo DT, Peck M, Subbiah RN, et al. The diagnostic role of T wave morphology biomarkers in congenital and acquired long QT syndrome: A systematic review. Ann Noninvasive Electrocardiol. 2022. 28(1):e13015. DOI: doi: 10.1111/anec.13015
  11. Singh M, Morin DP, Link MS. Sudden cardiac death in Long QT syndrome (LQTS), Brugada syndrome, and catecholaminergic polymorphic ventricular tachycardia (CPVT). Prog Cardiovasc Dis. 2019; 62(3):227–234. doi: 10.1016/j.pcad.2019.05.006
  12. Pelliccia A, Adami PE, Quattrini F, et al. Are Olympic athletes free from cardiovascular diseases? Systematic investigation in 2352 participants from Athens 2004 to Sochi 2014. Br J Sports Med. 2017;51(4):238–243. doi: 10.1136/bjsports-2016-096961
  13. Schnell F, Behar N, Carré F. Long-QT Syndrome and Competitive Sports. Arrhythm Electrophysiol Rev. 2018;7(3):187–192. doi: 10.15420/aer.2018.39.3
  14. Pelliccia A, Fagard R, Bjørnstad HH, et al. Recommendations for competitive sports participation in athletes with cardiovascular disease: a consensus document from the Study Group of Sports Cardiology of the Working Group of Cardiac Rehabilitation and Exercise Physiology and the Working Group of Myocardial and Pericardial Diseases of the European Society of Cardiology // Eur Heart J. 2005;14(26):1422–1445. doi: 10.1093/eurheartj/ehi325
  15. Priori S.G., Blomström-Lundqvist C., Mazzanti A., et al. 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: The Task Force for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the European Society of Cardiology (ESC). Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC) // Eur Heart J. 2015;(36):2793–867. doi: 10.1093/eurheartj/ehv316
  16. Ackerman MJ, Zipes DP, Kovacs RJ, et al. Eligibility and disqualification recommendations for competitive athletes with cardiovascular abnormalities: Task Force 10: The Cardiac Channelopathies: A Scientific Statement From the American Heart Association and American College of Cardiology. J Am Coll Cardiol. 2015;66(21):2424–2428. doi: 10.1016/j.jacc.2015.09.042
  17. Boitsov SA, Kolos IP, Lidov PI, et al. Natsional'nye rekomendatsii po dopusku sportsmenov s otkloneniyami so storony serdechno-sosudistoi sistemy k trenirovochno-sorevnovatel'nomu protsessu. Rational Pharmacotherapy in Cardiology. 2011;7(6):4–60. (In Russ.).

Supplementary files

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1. JATS XML
2. Fig. 1. 12-lead electrocardiogram in young athlete A., 16 years old

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3. Fig. 2. 12-lead electrocardiogram (standing) in young athlete A., 16 years old

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4. Fig. 3. Fragment of Holter ECG monitoring in young athlete A. The maximum duration of the QT interval

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5. Fig. 4. Fragment of Holter ECG monitoring in young athlete A. Prolongation of the QT interval

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6. Fig. 5. Fragment of Holter ECG monitoring in young athlete A. Ventricular extrasystoles, trigeminy

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7. Fig. 6. 12-lead electrocardiogram (standing) in young athlete A., 16 years old, after normalization of potassium concentration in blood serum. QT (V5) = 350 ms (A heart rate of 96 beats per min), QTc = 443 ms.

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8. Fig. 7. 12-lead electrocardiogram in young athlete Е., 10 years old

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9. Fig. 8. Fragment of Holter ECG monitoring in young athlete Е. Prolongation of the QT interval

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10. Fig. 9. Prolongation of the QT interval in the girl’s mother.

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