2022 Esc Guidelines for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death: What is New?
- Authors: Novikova T.N.1, Novikov V.I.1, Sayganov S.A.1, Shcherbakova V.A.1
-
Affiliations:
- North-Western State Medical University named after I.I. Mechnikov
- Issue: Vol 2, No 3 (2022)
- Pages: 7-30
- Section: Reviews
- URL: https://journals.rcsi.science/cardar/article/view/120363
- DOI: https://doi.org/10.17816/cardar110961
- ID: 120363
Cite item
Abstract
The review presents new indications to help with diagnosis and treatment of ventricular arrhythmia (VA) in patients with various etiologies of rhythm disturbances, including patients with coronary artery disease, cardiomyopathies, channelopathies, inflammatory heart disease, neuromuscular disease, and congenital heart defects. Algorithms for diagnostic evaluation at first presentation with VAs in patients without known cardiac disease are given.
Full Text
##article.viewOnOriginalSite##About the authors
Tatiana N. Novikova
North-Western State Medical University named after I.I. Mechnikov
Author for correspondence.
Email: novikova-tn@mail.ru
ORCID iD: 0000-0003-4655-0297
SPIN-code: 3401-0329
Associate professor department of cardiology, the associate professor of departament therapy and cardiology of M.S. Kushakovsky
Russian Federation, Saint PetersburgVladimir I. Novikov
North-Western State Medical University named after I.I. Mechnikov
Email: novikov-vi@mail.ru
ORCID iD: 0000-0002-2493-6300
SPIN-code: 6909-3377
MD, Doctor of medical sciences, Professor, Head of the Department of Functional Diagnostics
Russian Federation, St. PetersburgSergey A. Sayganov
North-Western State Medical University named after I.I. Mechnikov
Email: sergey.sayganov@szgmu.ru
ORCID iD: 0000-0001-8325-1937
SPIN-code: 2174-6400
Doctor of Medical Sciences, Professor
Russian Federation, Saint PetersburgVladislava A. Shcherbakova
North-Western State Medical University named after I.I. Mechnikov
Email: shcher.vl@yandex.ru
student
Russian Federation, Saint PetersburgReferences
- Zeppenfeld K, Tfelt-Hansen J, de Riva M, et al. 2022 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Eur Heart J. 2022;43(40): 3997–4126. doi: 10.1093/eurheartj/ehac262
- Faber TS, Gradinger R, Treusch S, et al. Incidence of ventricular tachyarrhythmias during permanent pacemaker therapy in low-risk patients results from the German multicentre EVENTS study. Eur Heart J. 2007;28(18):2238–2242. doi: 10.1093/eurheartj/ehm242
- Brignole M, Moya A, de Lange FJ, et al. 2018 ESC Guidelines for the diagnosis and management of syncope. Eur Heart J. 2018;39(21):1883–1948. doi: 10.1093/eurheartj/ehy037
- Middlekauff HR, Stevenson WG, Stevenson LW, Saxon LA. Syncope in advanced heart failure: high risk of sudden death regardless of origin of syncope. J Am Coll Cardio. 1993;21(1): 110–116. doi: 10.1016/0735-1097(93)90724-f
- Noda T, Shimizu W, Taguchi A, et al. Malignant entity of idiopathic ventricular fibrillation and polymorphic ventricular tachycardia initiated by premature extrasystoles originating from the right ventricular outflow tract. J Am Coll Cardiol. 2005;46(7):1288–1294. doi: 10.1016/j.jacc.2005.05.077
- Belhassen B, Viskin S. Idiopathic ventricular tachycardia and fibrillation. J Cardiovasc Electrophysiol. 1993;4(3):356–368. doi: 10.1111/j.1540-8167.1993.tb01236.x
- Zareba W, Platonov P. ECG patterns related to arrhythmias and sudden death: channelopathies, early repolarization, and pre-excitation. Camm JA, editor. The ESC Textbook of Cardiovascular Medicine. 3 edn, The European Society of Cardiology Series. Oxford: Oxford University Press, 2018. P. 382–389. doi: 10.1093/med/9780198784906.003.0074
- Binder T. Transthoracic echocardiography and the standard examination of specific cardiac structures. Camm JA, editor. The ESC Textbook of Cardiovascular Medicine. 3 edn, The European Society of Cardiology Series. Oxford: Oxford University Press, 2018. P. 426–431. doi: 10.1093/med/9780198784906.003.0085
- Voigt J-U. Left ventricular function, heart failure, and resynchronization therapy. Camm JA, editor. The ESC Textbook of Cardiovascular Medicine. 3 edn, The European Society of Cardiology Series. Oxford: Oxford University Press, 2018. P. 451–454. doi: 10.1093/med/9780198784906.003.0092
- Edvardsen T. Cardiomyopathies, myocarditis, and the transplanted heart. Camm JA, editor. The ESC Textbook of Cardiovascular Medicine. 3 edn, The European Society of Cardiology Series. Oxford: Oxford University Press, 2018. P. 456–460. doi: 10.1093/med/9780198784906.003.0094_update_001
- Cygankiewicz I. Ambulatory ECG monitoring. Camm JA, editor. The ESC Textbook of Cardiovascular Medicine. 3 edn, The European Society of Cardiology Series. Oxford: Oxford University Press, 2018. P. 393–400. doi: 10.1093/med/9780198784906.003.0798
- Gray B, Kirby A, Kabunga P, et al. Twelve-lead ambulatory electrocardiographic monitoring in Brugada syndrome: potential diagnostic and prognostic implications. Heart Rhythm. 2017;14(6):866–874. doi: 10.1016/j.hrthm.2017.02.026
- Karogiannis N, Senior R. Stress echocardiography. Camm JA, editor. The ESC Textbook of Cardiovascular Medicine. 3 edn, The European Society of Cardiology Series. Oxford: Oxford University Press, 2018. P. 432–434. doi: 10.1093/med/9780198784906.003.0086_update_001
- Di Marco A, Anguera I, Schmitt M, et al. Late gadolinium enhancement and the risk for ventricular arrhythmias or sudden death in dilated cardiomyopathy: systematic review and meta-analysis. JACC Heart Fail. 2017;5(1):28–38. doi: 10.1016/j.jchf.2016.09.017
- Josephson ME, Callans DJ. Using the twelve-lead electrocardiogram to localize the site of origin of ventricular tachycardia. Heart Rhythm. 2005;2(4):443–446. doi: 10.1016/j.hrthm.2004.12.014
- Nucifora G, Muser D, Masci PG, et al. Prevalence and prognostic value of concealed structural abnormalities in patients with apparently idiopathic ventricular arrhythmias of left versus right ventricular origin: a magnetic resonance imaging study. Circ Arrhythm Electrophysiol. 2014;7(3):456–462. doi: 10.1161/CIRCEP.113.001172
- Corrado D, Basso C, Leoni L, et al. Three-dimensional electroanatomic voltage mapping increases accuracy of diagnosing arrhythmogenic right ventricular cardiomyopathy/dysplasia. Circulation. 2005;111(23):3042–3050. doi: 10.1161/CIRCULATIONAHA.104.486977
- Casella M, Dello Russo A, Bergonti M, et al. Diagnostic yield of electroanatomic voltage mapping in guiding endomyocardial biopsies. Circulation. 2020;142(13):1249–1260. doi: 10.1161/CIRCULATIONAHA.120.046900
- Haanschoten DM, Adiyaman A, ‘t Hart NA, et al. Value of 3D mapping-guided endomyocardial biopsy in cardiac sarcoidosis: case series and narrative review on the value of electro-anatomic mapping-guided endomyocardial biopsies. Eur J Clin Invest. 2021;51(4):e13497. doi: 10.1111/eci.13497
- Tung R, Bauer B, Schelbert H, et al. Incidence of abnormal positron emission tomography in patients with unexplained cardiomyopathy and ventricular arrhythmias: the potential role of occult inflammation in arrhythmogenesis. Heart Rhythm. 2015;12(12):2488–2498. doi: 10.1016/j.hrthm.2015.08.014
- Palmisano A, Vignale D, Peretto G, et al. Hybrid FDG-PET/MR or FDG-PET/CT to detect disease activity in patients with persisting arrhythmias after myocarditis. JACC Cardiovasc Imaging. 2021;14(1):288–292. doi: 10.1016/j.jcmg.2020.03.009
- Dumas F, Geri G, Manzo-Silberman S, et al. Immediate percutaneous coronary intervention is associated with improved short- and long-term survival after out-of-hospital cardiac arrest. Circ Cardiovasc Interv. 2010;3(3):200–207. doi: 10.1161/CIRCINTERVENTIONS.109.913665
- Vyas A, Chan PS, Cram P, et al. Early coronary angiography and survival after out-of-hospital cardiac arrest. Circ Cardiovasc Interv. 2015;8(10):e002321. doi: 10.1161/CIRCINTERVENTIONS.114.002321
- Kalarus Z, Svendsen JH, Capodanno D, et al. Cardiac arrhythmias in the emergency settings of acute coronary syndrome and revascularization: an European Heart Rhythm Association (EHRA) consensus document, endorsed by the European Association of Percutaneous Cardiovascular Interventions (EAPCI), and European Acute Cardiovascular Care Association (ACCA). Europace. 2019;21(10):1603–1604. doi: 10.1093/europace/euz163
- Noc M, Fajadet J, Lassen JF, et al. Invasive coronary treatment strategies for out-of-hospital cardiac arrest: a consensus statement from the European association for percutaneous cardiovascular interventions (EAPCI)/stent for life (SFL) groups. EuroIntervention. 2014;10(1):31–37. doi: 10.4244/EIJV10I1A7
- Verma BR, Sharma V, Shekhar S, et al. Coronary angiography in patients with out-of-hospital cardiac arrest without ST-segment elevation: a systematic review and meta-analysis. JACC Cardiovasc Interv. 2020;13(19):2193–2205. doi: 10.1016/j.jcin.2020.07.018
- Barbarawi M, Zayed Y, Kheiri B, et al. Optimal timing of coronary intervention in patients resuscitated from cardiac arrest without ST-segment elevation myocardial infarction (NSTEMI): a systematic review and meta-analysis. Resuscitation. 2019;144:137–144. doi: 10.1016/j.resuscitation.2019.06.279
- Meng-Chang Y, Meng-Jun W, Xiao-Yan X, et al. Coronary angiography or not after cardiac arrest without ST segment elevation: a systematic review and meta-analysis. Medicine (Baltimore). 2020;99(41):e22197. doi: 10.1097/MD.0000000000022197
- Khan MS, Shah SMM, Mubashir A, et al. Early coronary angiography in patients resuscitated from out of hospital cardiac arrest without ST-segment elevation: a systematic review and meta-analysis. Resuscitation. 2017;121:127–134. doi: 10.1016/j.resuscitation.2017.10.019
- Welsford M, Bossard M, Shortt C, et al. Does early coronary angiography improve survival after out-of-hospital cardiac arrest? A systematic review with meta-analysis. Can J Cardiol. 2018;34(2):80–194. doi: 10.1016/j.cjca.2017.09.012
- Chelly J, Mongardon N, Dumas F, et al. Benefit of an early and systematic imaging procedure after cardiac arrest: insights from the PROCAT (Parisian Region Out of Hospital Cardiac Arrest) registry. Resuscitation. 2012;83(12):1444–1450. doi: 10.1016/j.resuscitation.2012.08.321
- Stiles MK, Wilde AAM, Abrams DJ, et al. 2020 APHRS/HRS expert consensus statement on the investigation of decedents with sudden unexplained death and patients with sudden cardiac arrest, and of their families. Heart Rhythm. 2021;18(1):e1–e50. doi: 10.1016/j.hrthm.2020.10.010
- Tseng ZH, Olgin JE, Vittinghoff E, et al. Prospective countywide surveillance and autopsy characterization of sudden cardiac death: POST SCD study. Circulation. 2018;137(25):2689–2700. doi: 10.1161/CIRCULATIONAHA.117.033427
- Fellmann F, van El CG, Charron P, et al. European recommendations integrating genetic testing into multidisciplinary management of sudden cardiac death. Eur J Hum Genet. 2019;27:1763–1773. doi: 10.1038/s41431-019-0445-y
- Yamamoto T, Takayama M, Sato N, et al. Inappropriate analyses of automated external defibrillators used during in-hospital ventricular fibrillation. Circ J. 2008;72(4):679–681. doi: 10.1253/circj.72.679
- Sweeney MO, Ruetz LL, Belk P, et al. Bradycardia pacing-induced short-long-short sequences at the onset of ventricular tachyarrhythmias: a possible mechanism of proarrhythmia? J Am Coll Cardiol. 2007;50(7):614–622. doi: 10.1016/j.jacc.2007.02.077
- Tseng ZH, Hayward RM, Clark NM, et al. Sudden death in patients with cardiac implantable electronic devices. JAMA Intern Med. 2015;175(8):1342–1350. doi: 10.1001/jamainternmed.2015.2641
- Lacour P, Buschmann C, Storm C, et al. Cardiac implantable electronic device interrogation at forensic autopsy: an underestimated resource? Circulation. 2018;137(25):2730–2740. doi: 10.1161/CIRCULATIONAHA.117.032367
- Curcio A, Mazzanti A, Bloise R, et al. Clinical presentation and outcome of Brugada syndrome diagnosed with the new 2013 criteria. J Cardiovasc Electrophysiol. 2016;27(8):937–943. doi: 10.1111/jce.12997
- Haïssaguerre M, Shah DC, Jaïs P, et al. Role of Purkinje conducting system in triggering of idiopathic ventricular fibrillation. Lancet. 2002;359(9307):677–678. doi: 10.1016/S0140-6736(02)07807-8
- Krahn AD, Healey JS, Chauhan V, et al. Systematic assessment of patients with unexplained cardiac arrest: cardiac arrest survivors with preserved ejection fraction registry (CASPER). Circulation. 2009;120(4):278–285. doi: 10.1161/CIRCULATIONAHA.109.853143
- van der Werf C, Hofman N, Tan HL, et al. Diagnostic yield in sudden unexplained death and aborted cardiac arrest in the young: the experience of a tertiary referral center in The Netherlands. Heart Rhythm. 2010;7(10):1383–1389. doi: 10.1016/j.hrthm.2010.05.036
- Waldmann V, Karam N, Bougouin W, et al. Burden of coronary artery disease as a cause of sudden cardiac arrest in the young. J Am Coll Cardiol. 2019;73(16):2118–2120. doi: 10.1016/j.jacc.2019.01.064
- Eckart RE, Scoville SL, Campbell CL, et al. Sudden death in young adults: a 25-year review of autopsies in military recruits. Ann Intern Med. 2004;141(11):829–834. doi: 10.7326/0003-4819-141-11-200412070-00005
- Kunadian V, Chieffo A, Camici PG, et al. An EAPCI expert consensus document on ischaemia with non-obstructive coronary arteries in collaboration with European Society of Cardiology Working Group on Coronary Pathophysiology & Microcirculation Endorsed by Coronary Vasomotor Disorders International Study Group. Eur Heart J. 2021;16(13):1049–1069. doi: 10.4244/EIJY20M07_01
- Rodrigues P, Joshi A, Williams H, et al. Diagnosis and prognosis in sudden cardiac arrest survivors without coronary artery disease: utility of a clinical approach using cardiac magnetic resonance imaging. Circ Cardiovasc Imaging. 2017;10(12):e006709. doi: 10.1161/CIRCIMAGING.117.006709
- White JA, Fine NM, Gula L, et al. Utility of cardiovascular magnetic resonance in identifying substrate for malignant ventricular arrhythmias. Circ Cardiovasc Imaging. 2012;5(1):12–20. doi: 10.1161/CIRCIMAGING.111.966085
- Basso C, Perazzolo Marra M, Rizzo S, et al. Arrhythmic mitral valve prolapse and sudden cardiac death. Circulation. 2015;132(7):556–566. doi: 10.1161/CIRCULATIONAHA.115.016291
- Basso C, Iliceto S, Thiene G, Perazzolo Marra M. Mitral valve prolapse, ventricular arrhythmias, and sudden death. Circulation. 2019;140(11):952–964. doi: 10.1161/CIRCULATIONAHA.118.034075
- Govindan M, Batchvarov VN, Raju H, et al. Utility of high and standard right precordial leads during ajmaline testing for the diagnosis of Brugada syndrome. Heart. 2010;96(23):1904–1908. doi: 10.1136/hrt.2010.201244
- Obeyesekere MN, Klein GJ, Modi S, et al. How to perform and interpret provocative testing for the diagnosis of Brugada syndrome, long-QT syndrome, and catecholaminergic polymorphic ventricular tachycardia. Circ Arrhythm Electrophysiol. 2011;4(6):958–964. doi: 10.1161/CIRCEP.111.965947
- Cheung CC, Mellor G, Deyell MW, et al. Comparison of ajmaline and procainamide provocation tests in the diagnosis of Brugada syndrome. JACC Clin Electrophysiol. 2019;5(4):504–512. doi: 10.1016/j.jacep.2019.01.026
- Antzelevitch C, Yan G-X, Ackerman MJ, et al. J-Wave syndromes expert consensus conference report: emerging concepts and gaps in knowledge. Europace. 2016;32(5):315–339. doi: 10.1016/j.joa.2016.07.002
- Garratt CJ, Antoniou A, Griffith MJ, et al. Use of intravenous adenosine in sinus rhythm as a diagnostic test for latent preexcitation. Am J Cardiol. 1990;65(13):868–873. doi: 10.1016/0002-9149(90)91428-9
- Foo FS, Stiles MK, Heaven D. Unmasking latent preexcitation of a right-sided accessory pathway with intravenous adenosine after unexplained sudden cardiac arrest. J Arrhythm. 2020;36(5):939–941. doi: 10.1002/joa3.12408
- Krahn AD, Healey JS, Chauhan VS, et al. Epinephrine infusion in the evaluation of unexplained cardiac arrest and familial sudden death: from the cardiac arrest survivors with preserved Ejection Fraction Registry. Circ Arrhythm Electrophysiol. 2012;5(5):933–940. doi: 10.1161/CIRCEP.112.973230
- Denis A, Sacher F, Derval N, et al. Diagnostic value of isoproterenol testing in arrhythmogenic right ventricular cardiomyopathy. Circ Arrhythm Electrophysiol. 2014;7(4):590–597. doi: 10.1161/CIRCEP.113.001224
- Marjamaa A, Hiippala A, Arrhenius B, et al. Intravenous epinephrine infusion test in diagnosis of catecholaminergic polymorphic ventricular tachycardia. J Cardiovasc Electrophysiol. 2012;23(2):194–199. doi: 10.1111/j.1540-8167.2011.02188.x
- Ackerman MJ, Khositseth A, Tester DJ, et al. Epinephrine-induced QT interval prolongation: a gene-specific paradoxical response in congenital long QT syndrome. Mayo Clin Proc. 2002;77(5):413–421. doi: 10.4065/77.5.413
- Shimizu W, Noda T, Takaki H, et al. Diagnostic value of epinephrine test for genotyping LQT1, LQT2, and LQT3 forms of congenital long QT syndrome. Heart Rhythm. 2004;1(3):276–283. doi: 10.1016/j.hrthm.2004.04.021
- Magnano AR, Talathoti N, Hallur R, et al. Sympathomimetic infusion and cardiac repolarization: the normative effects of epinephrine and isoproterenol in healthy subjects. J Cardiovasc Electrophysiol. 2006;17(9):983–989. doi: 10.1111/j.1540-8167.2006.00555.x
- Vyas H, Hejlik J, Ackerman MJ. Epinephrine QT stress testing in the evaluation of congenital long-QT syndrome: diagnostic accuracy of the paradoxical QT response. Circulation. 2006;113(11):1385–1392. doi: 10.1161/CIRCULATIONAHA.105.600445
- Krahn AD, Healey JS, Chauhan V, et al. Systematic assessment of patients with unexplained cardiac arrest: cardiac arrest survivors with preserved ejection fraction registry (CASPER). Circulation. 2009;120(4):278–285. doi: 10.1161/CIRCULATIONAHA.109.853143
- Waldmann V, Bougouin W, Karam N, et al. Coronary vasospasm-related sudden cardiac arrest in the community. J Am Coll Cardiol. 2018;72(7):814–815. doi: 10.1016/j.jacc.2018.05.051
- Etienne P, Huchet F, Gaborit N, et al. Mental stress test: a rapid, simple, and efficient test to unmask long QT syndrome. Europace. 2018;20(12):2014–2020. doi: 10.1093/europace/euy078
- Kop WJ, Krantz DS, Nearing BD, et al. Effects of acute mental stress and exercise on T-wave alternans in patients with implantable cardioverter defibrillators and controls. Circulation. 2004;109(15):1864–1869. doi: 10.1161/01.CIR.0000124726.72615.60
- Marcus FI, McKenna WJ, Sherrill D, et al. Diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia: proposed modification of the task force criteria. Eur Heart J. 2010;31(7):806–814. doi: 10.1093/eurheartj/ehq025
- Giudicessi JR, Ackerman MJ. Exercise testing oversights underlie missed and delayed diagnosis of catecholaminergic polymorphic ventricular tachycardia in young sudden cardiac arrest survivors. Heart Rhythm. 2019;16(8):1232–1239. doi: 10.1016/j.hrthm.2019.02.012
- Sy RW, van der Werf C, Chattha IS, et al. Derivation and validation of a simple exercise-based algorithm for prediction of genetic testing in relatives of LQTS probands. Circulation. 2011;124(20):2187–2194. doi: 10.1161/CIRCULATIONAHA.111.028258
- Adler A, van der Werf C, Postema PG, et al. The phenomenon of ‘QT stunning’: the abnormal QT prolongation provoked by standing persists even as the heart rate returns to normal in patients with long QT syndrome. Heart Rhythm. 2012;9(6):901–908. doi: 10.1016/j.hrthm.2012.01.026
- Schwartz PJ, Lia C. QTc behavior during exercise and genetic testing for the long-QT syndrome. Circulation. 2011;124(20): 2181–2184. doi: 10.1161/CIRCULATIONAHA.111.062182
- Wang Y, Scheinman MM, Chien WW, et al. Patients with supraventricular tachycardia presenting with aborted sudden death: incidence, mechanism and long-term follow-up. J Am Coll Cardiol. 1991;18(7):1711–1719. doi: 10.1016/0735-1097(91)90508-7
- Roberts JD, Gollob MH, Young C, et al. Bundle branch re-entrant ventricular tachycardia: novel genetic mechanisms in a lifethreatening arrhythmia. JACC Clin Electrophysiol. 2017;3(3): 276–288. doi: 10.1016/j.jacep.2016.09.019
- Santangeli P, Hamilton-Craig C, Dello Russo A, et al. Imaging of scar in patients with ventricular arrhythmias of right ventricular origin: cardiac magnetic resonance versus electroanatomic mapping. J Cardiovasc Electrophysiol. 2011;22(12):1359–1366. doi: 10.1111/j.1540-8167.2011.02127.x
- Haïssaguerre M, Duchateau J, Dubois R, et al. Idiopathic ventricular fibrillation: role of Purkinje system and microstructural myocardial abnormalities. JACC Clin Electrophysiol. 2020;6(6): 591–608. doi: 10.1016/j.jacep.2020.03.010
- Haïssaguerre M, Hocini M, Cheniti G, et al. Localized structural alterations underlying a subset of unexplained sudden cardiac death. Circ Arrhythm Electrophysiol. 2018;11(7):e006120. doi: 10.1161/CIRCEP.117.006120
- Mellor G, Laksman ZWM, Tadros R, et al. Genetic testing in the evaluation of unexplained cardiac arrest: from the CASPER (Cardiac Arrest Survivors With Preserved Ejection Fraction Registry). Circ Cardiovasc Genet. 2017;10(3):e001686. doi: 10.1161/CIRCGENETICS.116.001686
- Burns C, Bagnall RD, Lam L, et al. Multiple gene variants in hypertrophic cardiomyopathy in the era of next-generation sequencing. Circ-Genom Precis Med. 2017;10(4):e001666. doi: 10.1161/CIRCGENETICS.116.001666
- Winkel BG, Holst AG, Theilade J, et al. Nationwide study of sudden cardiac death in persons aged 1–35 years. Eur Heart J. 2011;32(8):983–990. doi: 10.1093/eurheartj/ehq428
- Bagnall RD, Weintraub RG, Ingles J, et al. A prospective study of sudden cardiac death among children and young adults. N Engl J Med. 2016;374:2441–2452. doi: 10.1056/NEJMoa1510687
- Winkel BG, Risgaard B, Sadjadieh G, et al. Sudden cardiac death in children (1–18 years): symptoms and causes of death in a nationwide setting. Eur Heart J. 2014;35(13):868–875. doi: 10.1093/eurheartj/eht509
- Risgaard B, Winkel BG, Jabbari R, et al. Burden of sudden cardiac death in persons aged 1 to 49 years: nationwide study in Denmark. Circ Arrhythm Electrophysiol. 2014;7(2):205–211. doi: 10.1161/CIRCEP.113.001421
- Hansen BL, Jacobsen EM, Kjerrumgaard A, et al. Diagnostic yield in victims of sudden cardiac death and their relatives. Europace. 2020;22(6):964–971. doi: 10.1093/europace/euaa056
- Lahrouchi N, Raju H, Lodder EM, et al. Utility of post-mortem genetic testing in cases of sudden arrhythmic death syndrome. J Am Coll Cardiol. 2017;69(17):2134–2145. doi: 10.1016/j.jacc.2017.02.046
- Tan HL, Hofman N, van Langen IM, et al. Sudden unexplained death: heritability and diagnostic yield of cardiological and genetic examination in surviving relatives. Circulation. 2005;112(2):207–213. doi: 10.1161/CIRCULATIONAHA.104.522581
- Lahrouchi N, Raju H, Lodder EM, et al. The yield of postmortem genetic testing in sudden death cases with structural findings at autopsy. Eur J Hum Genet. 2020;28:17–22. doi: 10.1038/s41431-019-0500-8
- Miles CJ, Behr ER. The role of genetic testing in unexplained sudden death. Transl Res. 2016;168:59–73. doi: 10.1016/j.trsl.2015.06.007
- Behr E, Wood DA, Wright M, et al. Cardiological assessment of first-degree relatives in sudden arrhythmic death syndrome. Lancet. 2003;362(9394):1457–1459. doi: 10.1016/s0140-6736(03)14692-2
- Behr ER, Dalageorgou C, Christiansen M, et al. Sudden arrhythmic death syndrome: familial evaluation identifies inheritable heart disease in the majority of families. Eur Heart J. 2008;29(13): 1670–1680. doi: 10.1093/eurheartj/ehn219
- Kumar S, Peters S, Thompson T, et al. Familial cardiological and targeted genetic evaluation: low yield in sudden unexplained death and high yield in unexplained cardiac arrest syndromes. Heart Rhythm. 2013;10(11):1653–1660. doi: 10.1016/j.hrthm.2013.08.022
- McGorrian C, Constant O, Harper N, et al. Family-based cardiac screening in relatives of victims of sudden arrhythmic death syndrome. Europace. 2013;15(7):1050–1058. doi: 10.1093/europace/eus408
- Mellor G, Raju H, de Noronha SV, et al. Clinical characteristics and circumstances of death in the sudden arrhythmic death syndrome. Circ Arrhythm Electrophysiol. 2014;7(6):1078–1083. doi: 10.1161/CIRCEP.114.001854
- Papadakis M, Papatheodorou E, Mellor G, et al. The diagnostic yield of Brugada syndrome after sudden death with normal autopsy. J Am Coll Cardiol. 2018;71(11):1204–1214. doi: 10.1016/j.jacc.2018.01.031
- Mellor G, Nelson CP, Robb C, et al. The prevalence and significance of the early repolarization pattern in sudden arrhythmic death syndrome families. Circ Arrhythm Electrophysiol. 2016;9(6):e003960. doi: 10.1161/CIRCEP.116.003960
- Priori SG, Wilde AA, Horie M, et al. Executive summary: HRS/EHRA/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes. Europace. 2013;15(10):1389–1406. doi: 10.1093/europace/eut272
- van der Werf C, Stiekema L, Tan HL, et al. Low rate of cardiac events in first-degree relatives of diagnosis-negative young sudden unexplained death syndrome victims during follow-up. Heart Rhythm. 2014;11(10):1728–1732. doi: 10.1016/j.hrthm.2014.05.028
- Wong LCH, Roses-Noguer F, Till JA, Behr ER. Cardiac evaluation of pediatric relatives in sudden arrhythmic death syndrome: a 2-center experience. Circ Arrhythm Electrophysiol. 2014;7(5): 800–806. doi: 10.1161/CIRCEP.114.001818
Supplementary files
