电邮这篇文章 THE COMPARATIVE ANALYSIS OF USING VIDEOTHORACOSCOPIC AND OPEN OPERATIONS FOR THE TREATMENT OF PATIENTS WITH TUMORS OF THYMUS
- 作者: Kovalenko V.V1, Dmitrochenko I.V1, Zakirov A.R1
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隶属关系:
- S.M. Kirov Military Medical Academy of the Ministry of Defense
- 期: 卷 39, 编号 1-1S (2020)
- 页面: 205-209
- 栏目: Articles
- URL: https://journals.rcsi.science/RMMArep/article/view/43429
- DOI: https://doi.org/10.17816/rmmar43429
- ID: 43429
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详细
Annually over 2,000,000 new cases of non-small-cell lung cancer are diagnosed worldwide. Preoperative N-staging is the most important diagnostic step to determine the prognosis and tactics of further treatment of patients with lung cancer. 20-30% of patients with early stage NSCLC have local or distant recurrence of the disease and 5-year survival in these patients varies from 40 to 85.5%. In this context, there is a need to develop new methods for intraoperative evaluation of regional lymph nodes. One of these methods is the detection and histological examination of a signal lymph node. This approach allows to perform a targeted evaluation of the first lymph node on the path of tumor spread in order to determine the state of the remaining regional lymphatic collectors. However, today there is no “ideal” method for detecting a signal lymph node. It requires developing new approaches to visualizing the pathways of lymph outflow. Objective: compare and evaluate the effectiveness of using methylene blue solutions to visualize lymphatic outflow pathways in laboratory animals (outbred rat). Animals were randomized into 2 groups - 8 in each. The first group was injected subcutaneously in the left thigh with a 1% aqueous solution of methylene blue, the second group - solution of methylene blue with human serum albumin. Depending on the time of exposure, animals were divided randomly into 4 subgroups - 15, 30, 45 and 60 minutes. There was evaluated the effectiveness of marking the pathways of lymph out-flow from the injection site. The effectiveness of marking the pathways of lymph outflow from the injection site was evaluated. As a result of the study, it was demonstrated that the use of a 1% methylene blue solution allows us to adequately visualize the pathways of lymph outflow. The disadvantage of the drug is migration to the next order LN with an exposure lasting 30 minutes. A solution of methylene blue in combination with human serum albumin has a comparable quality of LN visualization. However, it has a slow (> 60 minutes) migration, which is preferred during surgery.
作者简介
V. Kovalenko
S.M. Kirov Military Medical Academy of the Ministry of DefenseSt. Petersburg, Russia
I. Dmitrochenko
S.M. Kirov Military Medical Academy of the Ministry of DefenseSt. Petersburg, Russia
A. Zakirov
S.M. Kirov Military Medical Academy of the Ministry of DefenseSt. Petersburg, Russia
参考
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