SUBSTANTIATION OF THE TECHNOLOGY OF PREPARATION AND COMPOSITION OF DENTAL GEL WITH FURACILINE AND LIDOCAINE

Currently, most of the materials and medicines used to provide dental care are produced by foreign companies. Within the framework of foreign medicines substitution program, the development and implementation of less expensive and quite effective dental medicines of domestic production are relevant. In order to expand the range of dental medicines, the composition and technology of a dental gel with analgesic, antimicrobial and anti-inflammatory effects are substantiated. Furacilin and lidocaine hydrochloride with correspondingly expressed antimicrobial and local analgesic are selected as active substances for the complex effect on the inflammatory process of the gums. As possible gel bases, solutions of natural and semi-synthetic origin in various concentrations were studied: methyl cellulose (MC), gelatin, polyvinyl alcohol (PVA) as the most harmless and affordable high molecular weight compounds (HMWCs). Anhydrous glycerin and polyethylene oxide-400 (PEO-400) were used as plasticizers in an amount of 4% to 5% by weight of the gel. The results of the bioavailability study made it possible to select gel-forming bases for further studies. These gel-forming bases provide the optimal degree and rate of active substances release, as well as those with sufficient sedimentation stability and spreading ability.

determination of bioavailability, furaciline, dental gel, pharmaceutical technology, lidocaine