Medical and social consequences of confusion syndrome that developed in the acute period of ischemic stroke

详细

AIM: To assess the dynamics of cognitive functions in patients in whom the acute period of ischemic stroke was accompanied by the confusion syndrome, in comparison with patients in whom the acute period of stroke was not accompanied by the development of confusion. To assess the impact of clinical features of confusion syndrome on the development of post-stroke cognitive impairment, mortality, and patient care burden.

MATERIALS AND METHODS: The study involved 99 patients, 55 of whom developed severe confusion during the acute period of stroke, and 44 patients whose ischemic stroke was not complicated by the development of confusion syndrome. The groups were homogeneous in terms of the main etiological factors: age, degree of pre-stroke cognitive impairment. The study assessed the impact of the development of confusional syndrome on the outcome.

RESULTS: Confusion syndrome that develops in the acute period of ischemic stroke significantly increases the risk of developing or worsening existing cognitive impairment, mortality, dependence on care, and the burden on caregivers.

CONCLUSION: Being a serious complication, confusion syndrome requires monitoring of qualitative and quantitative indicators of consciousness in the acute period of ischemic stroke, prevention and, if detected, immediate correction of confusion syndrome.

作者简介

Yuriy Khlystov

Military Medical Academy

编辑信件的主要联系方式.
Email: khlysyura@yandex.ru
ORCID iD: 0000-0001-5620-5986
SPIN 代码: 8208-5103
Scopus 作者 ID: 53663593100

assistant to the Head of the Сlinic

俄罗斯联邦, Saint Petersburg

Nikolay Tsygan

Military Medical Academy

Email: 1860n@mail.ru
ORCID iD: 0000-0002-5881-2242
SPIN 代码: 1006-2845
Scopus 作者 ID: 37066611200
Researcher ID: H-9132-2016

M.D., D.Sc. (Medicine), Professor

俄罗斯联邦, Saint Petersburg

Sergey Kolomentsev

Military Medical Academy

Email: skolomencev@yandex.ru
ORCID iD: 0000-0002-3756-6214
SPIN 代码: 6439-6701

M.D., PhD (Medicine)

俄罗斯联邦, Saint Petersburg

Evgeny Kurasov

Military Medical Academy

Email: doc4678@mail.ru
ORCID iD: 0000-0003-3616-6574
SPIN 代码: 4961-0342

M.D., D.Sc. (Medicine), Professor

俄罗斯联邦, Saint Petersburg

Miroslav Odinak

Military Medical Academy

Email: odinak@rambler.ru
ORCID iD: 0000-0002-7314-7711
SPIN 代码: 1155-9732
Scopus 作者 ID: 7003327776
Researcher ID: I-6024-2016

M.D., Corresponding Member of the Russian Academy of Sciences, D.Sc. (Medicine), Professor

俄罗斯联邦, Saint Petersburg

Igor' Litvinenko

Military Medical Academy

Email: litvinenkoiv@rambler.ru
ORCID iD: 0000-0001-8988-3011
SPIN 代码: 6112-2792
Scopus 作者 ID: 35734354000
Researcher ID: F-9120-2013

M.D., D.Sc. (Medicine), Professor

俄罗斯联邦, Saint Petersburg

参考

  1. Dahl MH, Ronning OM, Thommessen B. Delirium in acute stroke — prevalence and risk factors. Acta Neurol Scand Suppl. 2010;22(190):39–43. doi: 10.1111/j.1600-0404.2010.01374.x
  2. Gustafson Y, Olsson T, Erikkson S, et. al. Acute confusional state (delirium) in stroke patients. Cerebrovasc Dis. 1991;1(1):257–264. doi: 10.1159/000108852
  3. Miu DK, Yeung JC. Incidence of post-stroke delirium and 1-year outcome. Geriatrics and Gerontology International. 2012;13(1): 123–129. doi: 10.1111/j.1447-0594.2012.00871.x
  4. Nydahl P, Margraf NG, Ewers A. [Delirium in stroke patients: Critical analysis of statistical procedures for the identification of risk factors]. Med Klin Intensivmed Notfmed. 2017;112(3):258–264. (In German) doi: 10.1007/s00063-016-0257-6
  5. Qu J, Chen Y, Luo G, et al. Delirium in the acute phase of ischemic stroke: incidence, risk factors, and effects on functional outcome. J Stroke Cerebrovasc Dis. 2018;27(10):2641–2647. doi: 10.1016/j.jstrokecerebrovasdis.2018.05.034
  6. Pasińska P, Wilk A, Kowalska K, et al. The long-term prognosis of patients with delirium in the acute phase of stroke: PRospective Observational POLIsh Study (PROPOLIS). J Neurol. 2019;266(11): 2710–2717. doi: 10.1007/s00415-019-09471-1
  7. Barman A, Pradhan D, Bhattacharyya P, et al. Diagnostic accuracy of delirium assessment methods in critical care patients. J Crit Care. 2018;44:82–86. doi: 10.1016/j.jcrc.2017.10.013
  8. Vaynshenker YuI, Cinzerling VA, Melyucheva LA, et al. Multipattern botulinum toxin therapy of post-comatose long-term consciousness disorders: central effects. Bulletin of the Russian Military Medical Academy. 2019;(2(66)):78–87. (In Russ.)
  9. Litvinenko IV, Odinak MM, Khlystov YuV, et al. Efficacy and safety of rivastigmine (exelon) in the confusion syndrome in the acute phase of ischemic stroke. The Korsakov’s Journal of Neurology and Psychiatry. 2010;110(11-2):36–41. (In Russ.)
  10. Litvinenko IV, Odinak MM, Mogil’naya VI, Emelin AYu. Efficacy and safety of galantamine (reminyl) in the treatment of dementia in patients with Parkinson’s disease (open-lable controlled trial). The Korsakov’s Journal of Neurology and Psychiatry. 2007;107(12): 25–34. (In Russ.)
  11. Ojagbemi A, Ffytche DH. Are stroke survivors with delirium at higher risk of post-stroke dementia? Current evidence and future directions. Int J Geriatr Psychiatry. 2016;31(7):1289–1294. doi: 10.1002/gps.4506
  12. Droś J, Kowalska K, Pasińska P, et al. Delirium Post-Stroke-Influence on Post-Stroke Dementia (Research Study-Part of the PROPOLIS Study). Clin Med. 2020;9(7):2165. doi: 10.3390/jcm9072165
  13. Inouye SK, van Dyck CH, Alessi CA, et al. Clarifying confusion: The confusion assessment method. A new method for detection of delirium. Ann Intern Med. 1990;113(12):941–948. doi: 10.7326/0003-4819-113-12-941
  14. Trzepacz PT, Baker RW., Greenhouse J. A symptom rating scale for delirium. Psychiatry Res. 1988;23(12):89–97. doi: 10.1007/springerreference_169912
  15. Trzepacz PT. The Delirium Rating Scale. Its use in consultation-liaison research. Psychosomatics. 1999;40(3):193–204. doi: 10.1016/s0033-3182(99)71235-1
  16. Folstein MF, McHugh PR. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12(3):189–198. doi: 10.1016/0022-3956(75)90026-6
  17. Dubois B, Slachevsky A, Litvan I, et al. The FAB: A frontal assessment battery at bedside. Neurology. 2000;55(11):1621–1626. doi: 10.1212/wnl.55.11.1621
  18. Sunderland T. Clock drawing in Alzheimer’s disease: A novel measure of dementia severity. J Am Geriatr Soc. 1989;37(8):725–729. doi: 10.1111/j.1532-5415.1989.tb02233.x
  19. Dubois B, Touchon J, Portet F, et al. [«The 5 words»: a simple and sensitive test for the diagnosis of Alzheimer’s disease]. Presse Med. 2002;31(36):1696–1699. (In French)
  20. Jorm AF, Jacomb PA. The informant questionnaire on cognitive decline in the elderly (IQCODE): socio-demographic correlates, reliability, validity and some norms. Psychol Med. 1989;19(4): 1015–1022. doi: 10.1017/s0033291700005742
  21. Zigmond AS, Snaith RP. The Hospital Anxiety and Depression Scale. Acta Psychiatr Scand. 1983;67(6):361–370. doi: 10.1037/t03589-000
  22. Zarit SH, Reever KE, Bach-Peterson J. Relatives of the impaired elderly: correlates of feelings of burden. Gerontologist. 1980;20(6):649–655. doi: 10.1093/geront/20.6.649

补充文件

附件文件
动作
1. JATS XML

版权所有 © Eco-Vector, 2023

Creative Commons License
此作品已接受知识共享署名-非商业性使用-禁止演绎 4.0国际许可协议的许可。

Согласие на обработку персональных данных

 

Используя сайт https://journals.rcsi.science, я (далее – «Пользователь» или «Субъект персональных данных») даю согласие на обработку персональных данных на этом сайте (текст Согласия) и на обработку персональных данных с помощью сервиса «Яндекс.Метрика» (текст Согласия).