METABOLIC SYNDROME SIGNS IN KIDNEY STONE DISEASE. CAUSES OF DEATH

According to several population studies, the prevalence of urolithiasis in the world is from 3.5 to 9.6%, manifestations of the metabolic syndrome in the general population are found in 14-39% of cases. The frequency of occurrence of pathology data has a strong upward trend. Epidemiological data indicate a more frequent development of urolithiasis in patients with manifestations of the metabolic syndrome. The aim of the study is to study the manifestations of the metabolic syndrome in urolithiasis and the causes of deaths. The autopsy protocols of the deceased suffering from urolithiasis with clinical epicrisis data were analyzed. The metabolic syndrome in the cases considered was established according to the criteria of the National Cholesterol Education Program (NCEP) and supplemented by the presence of clinical manifestations and morphological changes in organs and tissues. In most cases (70%), there were clinical and laboratory manifestations of the metabolic syndrome in urolithiasis, more often in men aged 39-90 years. A pathological study determines its indirect signs: abdominal and visceral obesity, systemic macro and microangiopathy with predominant damage to the kidneys and heart, fatty liver. The metabolic syndrome in urolithiasis contributes to the formation of pathogenetically related metabolic disorders, systemic macro- and microangiopathy, which leads to a generalization of the purulent process in the kidneys against the background of immunodeficiency. The cause of deaths was multiple organ failure due to urosepsis. In the group without manifestations of the metabolic syndrome (30%), among men aged 57-71 years, complications and causes of death are caused by the development of myocardial infarction, pulmonary embolism.

metabolic syndrome, kidney stone disease, type 2 diabetes, metabolic disorder, clinical and laboratory criteria, morphology, causes of death