DEVELOPMENT OF METHODS OF IDENTIFICATION AND QUANTITATIVE DETERMINATION OF LIDOCAINE HYDRO- CHLORIDE AND FURACILIN IN DENTAL GEL

Based on previous study, the results of substantiating the composition and technology of a dental medicinal gel containing furacilin and lidocaine hydrochloride for the treatment of oral cavity were developed. This report presents the results of the development of methods for standardizing a dental medicinal gel containing furacilin and lidocaine hydrochloride. Based on the studies, chemical reactions are proposed that allow the authenticity of furacin and lidocaine hydrochloride to be established with the joint presence in the gel. The developed methods are characterized by ease of implementation, reliability of results, sensitivity of reactions and exclude the separation of ingredients. Methods for the quantitative determination of active substances in a gel are developed on the basis of studying the absorption spectra of furacin, lidocaine hydrochloride and the polymer base in the range from 200 nm to 400 nm. It was found that the optimal method for quantitative determination by spectrophotometry for a given composition of a drug is a combination of the isolated absorption method for furacilin and the calculation method for lidocaine hydrochloride. This combination of spectrophotometry options allows to conduct the quantitative determination of both gel ingredients in the joint presence without prior separation with a relative error for furacilin (99.9 ± 0.9)%, lidocaine hydrochloride (101.0 ± 1.6)%.

spectrophotometry, quantification, identification, lidocaine hydrochloride, dental gel, pharmaceutical technology, furaciline