THE EXPERIMENTAL EFFICIENCY EVALUATION OF RESPIRATORY THERAPY FOR TOXIC PULMANORY EDEMA IN ACUTE INTOXICATION WITH PYROLYSIS PRODUCTS OF FLUOROPLASTICS

Pulmonotoxicants are the substances causing structural and functional disorders of respiratory system. During thermal destraction of polytetrafluoroethylene, a highly toxic perfluoroisobutylene is produced, its inhalation effects lead to the development of acute pulmonary edema and death in injured. In the study, it was found that the inhalation effect of pyrolysis products of fluoroplast-4 (containing perfluorizobutylene) on laboratory animals leads to lung damage. Macro - and microscopic changes characteristic of toxic pulmonary edema with a predominance of the alveolar component were noted. Increasing of (p<0.05) alveolar macrophages and neutrophils was noted at the analysis of bronchial-alveolar lavage fluid, what indicates the development of the inflammatory process. Inhalation use of oxygen-helium mixture for 6 hours after influence, led to increasing the average life expectancy of laboratory animals (p=0,013). During the analysis the magnitude of the lung coefficient of animals withdrawn from the experiment 6 hours after intoxication, there was a decrease in the pulmonary coefficient (p=0.03) compared to animals that did not receive treatment (6,8 and 9,6 respectively). The experimental findings can be used for further efficiency evaluation of the use of oxygen-helium mixture for the correction of toxic pulmonary edema caused by intoxication with perfluorizobutylene and other pulmonotoxicants.

pulmonotoxicants, fluoroplast, pyrolysis, perfluorizobutylene, toxic pulmonary edema, oxygen-helium mixture