REPARATIVE HISTOGENESIS OF MOUSE’S ADIPOSE TISSUE AT MECHANICAL DAMAGE


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Abstract

The features of the interaction of various cellular differs of mouse hypodermis in reparative histogenesis at the light level were identified and described. As a result of the study, it was found that at different periods of reparative histogenesis, the cellular differs of the hypodermis have their own distinctive morphometric characteristics, thanks to which it is possible to determine the period after application of the wound and more precisely to zone the wound area. In the first phase of reparative histogenesis associated with the inflammation reaction, adipocyte plasmolemma ruptures and active lipid release, fat embolism of the microvasculature and blood cell migration into the intercellular substance with the formation of a leukocyte shaft at the border with necrotic tissue were observed. The ratio in the repair histion at this period increases towards neutrophils and macrophages that infiltrate hypodermis. In the second phase of reparative histogenesis associated with the formation of granulation tissue, adipogenesis was observed in the hypodermis. Therefore, the ratio in the repair histion changes in the direction of increasing the number of adipocytes, but has not yet reached the norm.

About the authors

A. N Davjdenko

S.M. Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation

St. Petersburg, Russia

O. E Mirgorodskaya

S.M. Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation

St. Petersburg, Russia

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Copyright (c) 2020 Davjdenko A.N., Mirgorodskaya O.E.

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