WATERHOUSE-FRIDERICHSEN SYNDROME AS MAIN REASON OF DEATH IN RUSSIAN ARMED FORCES SOLDIERS IN GENERALIZED FORM OF MENINGOCOCCAL INFECTION

For military collectives outbreaks and the increased incidence of meningococcal infection are an emergency problem. Meningococcal disease has been known since ancient times in such a form as epidemic cerebrospinal meningitis, isolated and described in detail in 1805 p. G. Vieusseux after the big outbreak in Geneva. In 1889, W. Osler isolated the pathogen from the blood, this discovery proved that meningococcus causes not only meningitis, but also other clinical forms of the disease. In 1965, the ICD-8 World Health Assembly introduced a new name for the disease, meningococcal infection. In the period from 1995 to 2016, the dynamics of the gray-group landscape of meningococci, causing a generalized form of meningococcal infection, changed. An increase in the incidence of meningococcal infection caused by serogroup W135 is observed: in 1998, W135 occupied 2-3% of epidemic serogroups such as A, В, С; in 2016, the number of meningococcal infections caused by W135 was 46. Waterhouse-Frederichsen syndrome, a clinical syndrome due to acute adrenal cortex function disorder due to hemorrhages in both adrenal glands, is a consequence of acute reduction or complete cessation of gluco- and mineralocorticoid hormone production without prior chronic adrenal insufficiency. This syndrome was first described by J. Voelcker in 1884. A more complete description of the clinical picture of acute adrenal insufficiency was given by R. Waterhouse in 1911. The aim of the study is to study Waterhouse-Friederichsen syndrome and to identify the incidence of this syndrome as the cause of death in military personnel in a generalized form of meningococcal infection.

meningococcal infection, military personnel, Waterhouse-Friderichsen syndrome, epidemic process, suprarenal glands