Acute appendicitis in adults: only clinical and laboratory diagnostics, only imaging, or both?

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Abstract

The presented article is devoted to the discussion of the necessity and expediency of using medical visualization diagnostics — radiological imaging — of acute appendicitis as an independent or complex approach in combination with clinical and laboratory data. Until now, the clinical diagnosis of each individual case of acute appendicitis is complicated, and its formulation requires combining clinical, laboratory and imaging data, since it includes a wide range of differential diagnoses depending on age and gender. The literature provides data that the frequency of negative appendectomies based on the results of a clinical examination can be up to 28.2%. Radiological imaging is used as an adjunct to clinical diagnostics using ultrasound examination, computed tomography and magnetic resonance imaging, but the role of the latter is limited by the duration of the study, increased cost, unavailability around the clock, as well as the presence of absolute contraindications. Sonography and computed tomography in diagnostics have a number of advantages and disadvantages, and the question of choosing a specific method still causes scientific controversy. We also provide illustrative clinical examples demonstrating echographic and computed tomographic imaging manifestations of acute appendicitis, as well as discuss visualization signs. For a patient with suspected acute appendicitis, in order to increase the accuracy of diagnosis, reduce complications or the need of undergoing unnecessary diagnostic and therapeutic procedures, a multidisciplinary and multimodal approach is necessary, taking into account age, gender and constitution, however, the question of choosing the optimal method of medical imaging in the diagnosis of acute appendicitis between ultrasound and computed tomography remains debatable.

About the authors

Vladimir V. Ryazanov

Saint Petersburg State Pediatric Medical University; Military Medical Academy

Email: 79219501454@yandex.ru
ORCID iD: 0000-0002-0037-2854

MD, Dr. Sci. (Medicine), Associate Professor

Russian Federation, Saint Petersburg; Saint Petersburg

Gul’naz K. Sadykova

Saint Petersburg State Pediatric Medical University; Military Medical Academy

Email: kokonya1980@mail.ru
ORCID iD: 0000-0002-6791-518X

MD, Cand. Sci. (Medicine)

Russian Federation, Saint Petersburg; Saint Petersburg

Gennadiy E. Trufanov

Almazov National Medical Research Centre

Email: trufanovge@mail.ru
ORCID iD: 0000-0002-1611-5000

MD, Dr. Sci. (Medicine), Professor

Russian Federation, Saint Petersburg

Igor’ S. Zheleznyak

Military Medical Academy

Email: izvestiavmeda@mail.ru
ORCID iD: 0000-0001-7383-512X

MD, Dr. Sci. (Medicine), Professor

Russian Federation, Saint Petersburg

Sergey S. Bagnenko

Saint Petersburg State Pediatric Medical University; Petrov National Medical Research Centre of Oncology

Email: bagnenko_ss@mail.ru
ORCID iD: 0000-0002-4131-6293

MD, Dr. Sci. (Medicine), Associated Professor

Russian Federation, Saint Petersburg; Saint Petersburg

Victor V. Ipatov

Military Medical Academy

Author for correspondence.
Email: mogidin@mail.ru
ORCID iD: 0000-0002-9799-4616

MD, Cand. Sci. (Medicine)

Russian Federation, Saint Petersburg

Leonid V. Voronkov

Military Medical Academy

Email: izvestiavmeda@mail.ru
ORCID iD: 0000-0002-0780-0735

MD, Cand. Sci. (Medicine)

Russian Federation, Saint Petersburg

Gennadiy G. Romanov

Military Medical Academy

Email: izvestiavmeda@mail.ru
ORCID iD: 0000-0001-5987-8158

MD, Cand. Sci. (Medicine)

Russian Federation, Saint Petersburg

Georgiy O. Bagaturia

Saint Petersburg State Pediatric Medical University

Email: geobag@mail.ru
ORCID iD: 0000-0001-5311-1802

MD, Dr. Sci. (Medicine), Professor

Russian Federation, Saint Petersburg

References

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Supplementary files

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1. JATS XML
2. Fig. 1. CT images in the axial plane in the native phase (а, г), arterial phase (б, д), portovenous phase (в, е) at two levels demonstrate the accumulation of contrast agent by the walls of the appendicular process (arrow) in different post-contrast phases in comparison with the native. In the lumen of the appendix, fecal matter is visualized against the background of liquid contents (dotted arrow)

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3. Fig. 2. CT images in the axial plane in the native phase (a), arterial phase (б), portovenous phase (в) demonstrate (б, в) the accumulation of contrast agent by the wall of the appendicular process (arrow) with a clearer differentiation of the walls from the contents in the lumen of the appendix (dotted arrow)

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4. Fig. 3. Sonograms of the inflamed appendix (arrows) in B-mode on the short axis (а) and on the long axis (б)

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5. Fig. 4. CT images of two patients with acute appendicitis in the frontal plane in the native phase, indicating the diameters of the appendicular processes

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6. Fig. 5. CT images in the frontal plane in the native phase (а, б) of a normal appendicular process with a diameter of 8,09 mm and containing gas bubbles (arrows) without clinical signs of acute appendicitis

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7. Fig. 6. Sonograms in B-mode along the long axis of appendixes (а–в), CT images in the axial plane in the native phase (г–е) only with liquid contents in the appendix (а, г), with a single appendicolitis (б, д), with multiple appendicolitis (в, е). Appendicolites are indicated by arrows

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8. Fig. 7. CT images in the frontal (a) and sagittal (b) planes in the native phase: around the appendicular process (arrows) there is a heavy thickening of adipose tissue. Dome of the cecum (dotted arrow)

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9. Fig. 8. B-mode sonograms (а — longitudinal scan of the appendix; б — transverse scan of the appendix). The inflamed appendix (arrows) is surrounded by inflamed adipose tissue of higher echogenicity

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10. Fig. 9. On native CT-tomograms in the axial (а) and frontal (б) planes and corresponding sonograms (в, г), the appendix is visualized (walls 4 mm thick, in the lumen (up to 6 mm) heterogeneous contents) (arrow) with edema of the walls of the cecum (dotted arrow). Adjacent adipose tissue without visible changes

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11. Fig. 10. On native CT scans, an abscess (arrow) is visualized in the axial plane with an inflamed appendix indistinguishable against its background. Dome of the cecum (dotted arrow)

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12. Fig. 11. Native CT-tomograms in the axial plane. Acute appendicitis with reactive regional lymphadenopathy (а, arrow), edema of the adjacent adipose tissue (б, arrow), with the presence of appendicolitis (в, arrow), thickening of the walls of the cecum (в, dotted arrow), small abdominal effusion (г, arrow)

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13. Fig. 12. CT images in the frontal (а) and axial (б) planes in the arterial phase. CT angiography accidentally revealed appendicolitis at the mouth of the appendicular process (arrows) with an increase in the diameter of the appendix to 10mm, without clinical and laboratory data for acute inflammation. The dome of the cecum (а, dotted arrow)

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14. Fig. 13. B-mode sonograms (а — longitudinal scan of the appendix; б — transverse scan of the appendix). Inflamed appendix (arrows) with clearly differentiable walls, contents in the lumen

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15. Fig. 14. CT images in the frontal plane in the native phase (а) and post-contrast phase (б): the appendicular process (arrows) is enlarged (12 mm), the walls are strengthened, moderate striation of periappendicular adipose tissue

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16. Fig. 15. CT-tomograms (a) in three planes at the level of the appendix with the presence of appendicolitis in the lower third (in the images corresponds to the intersection point of the secant lines) with obstruction of the lumen and expansion of the lumen above the obstacle, with swelling of the periappendicular fatty tissue. Sonograms (б–г) in B-mode demonstrate appendicolitis and areas of the appendix without expansion of the lumen and sac-like expansion above the obstacle (arrow)

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