COMPARATIVE EVALUATION OF EFFICIENCY OF USE OF INTRAVITREAL DRUGS IN THERAPY OF POSTTHROMBOTIC RETINOPATHY

Objective: conduct a comparative evaluation of the effectiveness of treatment of postthrombotic retinopathy with the use of drugs for intravitreal treatment - anti-VEGF drugs and biodegradable implant “Ozurdex”. Materials and methods. 40 patients (27 women, 13 men) with postthrombotic macular edema who underwent thrombosis of the upper-temporal branch of the central vein of the retina were observed. The age from the onset of the disease was from 1 to 3 months. Two groups were formed: the first group included 20 patients (20 eyes) who received intravitreal administration of an anti-VEGF preparation (ranibizumab); the second group consisted of 20 patients (20 eyes) who received an intravitreal injection of a biodegradable implant containing 0.7 mg of dexamethasone. We selected patients with non-ischemic type of thrombosis of the upper temporal branch of the central vein of the retina for two clinical groups. Results. After the treatment, after 1 month, both groups showed positive dynamics: an increase in the best corrected visual acuity, a decrease in the height and area of spread of the macular edema. In the first group of patients studied, a slight increase in the best corrected visual acuity was observed in 75% of patients a month later, in 60% of patients a slight decrease in the height of postthrombotic macular edema and in 55% of patients a significant decrease in the area of spread of macular edema. In the second group of patients, a significant increase in the bestcorrected visual acuity was observed in 60% of the patients in a month of observation, a significant significant decrease in the height of the macular edema in 70% of patients, and a moderate decrease in the area of the macular edema in 55% of the patients. Conclusion. In the course of the studies it was found that at the beginning of the treatment of postthrombotic retinopathy, it is necessary to approach the choice of the drug for intravitreal therapy individually (bibliography: 4 refs).

intravitreal drugs, macular edema, post- thrombotic retinopathy