Fighting SARS-CoV-2 infection: experience and prospects

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Abstract

BACKGROUND: COVID-19 is an international emergency. The Military Medical Academy, including the Department and Clinic of Infectious Diseases (with a course in medical parasitology and tropical diseases) are actively involved in the fight against the COVID-19 pandemic, and are also studying the pathogenesis, diagnosis and treatment of this disease.

AIM: to systematize the work done at the Military Medical Academy in relation to the fight against a new coronavirus infection.

MATERIALS AND METHODS: This article provides a brief description of the studies conducted in relation to COVID-19.

RESULTS: The department’s view of the infection caused by SARS-CoV-2 is presented, the main indicators of the work of the clinic of infectious diseases in the fight against COVID-19 are briefly reflected, and their own research in the field of this infectious disease is demonstrated.

CONCLUSION: Based on our scientific work, our experience in treating patients with a new coronavirus infection, the main conclusions and recommendations are formulated:

  1. It is necessary to take into account the clinical feature of COVID-19 — a long initial period (up to 8 days), which creates the illusion of imaginary well-being and contributes to late hospitalization.
  2. PCR is not an ideal diagnostic method, which creates the possibility of obtaining a false negative result. In this regard, clinical, epidemiological and radiological diagnostics are decisive.
  3. The organization of early active detection of patients with all clinical forms of infection caused by SARS-CoV-2, and their timely hospitalization helps to reduce the risk of developing a severe course, complications and epidemiological danger of patients.
  4. Complex antiviral and anticoagulant therapy should be early (up to 5 days from the clinical manifestation), proactive, aimed at reducing the likelihood of developing pneumonia with respiratory failure and thrombosis of the LA branches.
  5. Anti-inflammatory therapy increases the survival of patients with severe COVID-19 and should be administered as early as possible with a preventive goal at the first minimal clinical and laboratory signs of a hyperinflammatory response.

About the authors

Konstantin V. Zhdanov

Military Medical Academy

Email: zhdanovkv.vma@gmail.com
SPIN-code: 7895-2075
Scopus Author ID: 6602691874

M.D., D.Sc. (Medicine), Professor, Chief of Infectious Diseases (with a course in Medical Parasitology and Tropical Diseases) Department

Russian Federation, Saint Petersburg

Konstantin V. Kozlov

Military Medical Academy

Author for correspondence.
Email: kosttiak@mail.ru
ORCID iD: 0000-0002-4398-7525
SPIN-code: 7927-9076
Scopus Author ID: 56924908500
ResearcherId: H-9944-2013

M.D., D.Sc. (Medicine), Professor of Infectious Diseases (with a course in Medical Parasitology and Tropical Diseases) Department

Russian Federation, Saint Petersburg

Oleg V. Maltsev

Military Medical Academy

Email: olegdzein@mail.ru
ORCID iD: 0000-0002-6286-9946
SPIN-code: 3570-2580

M.D., Ph.D. (Medicine), Deputy Chief of Infectious Diseases (with a course in Medical Parasitology and Tropical Diseases) Department

Russian Federation, Saint Petersburg

Panteley I. Miklush

Military Medical Academy

Email: www.pantik.ru@mail.ru
ORCID iD: 0000-0002-5668-462X
SPIN-code: 1599-4487

senior resident of the clinic of Infectious Diseases (with a course in Medical Parasitology and Tropical Diseases) Department

Russian Federation, Saint Petersburg

Valerian V. Sharabhanov

Military Medical Academy

Email: haes87@mail.ru
ORCID iD: 0000-0002-0526-6006
SPIN-code: 7631-4918
Scopus Author ID: 57217384924
ResearcherId: AAB-7127-2022

M.D., Ph.D. (Medicine), senior resident of the clinic of Infectious Diseases (with a course in Medical Parasitology and Tropical Diseases) Department

Russian Federation, Saint Petersburg

Kristina V. Kasyanenko

Military Medical Academy

Email: dr.snegur@gmail.com
ORCID iD: 0000-0001-9294-7346
SPIN-code: 4286-2057

lecturer at the Infectious Diseases (with a course in Medical Parasitology and Tropical Diseases) Department

Russian Federation, Saint Petersburg

Vera V. Gordienko

Military Medical Academy

Email: ivanovavmeda@gmail.com
ORCID iD: 0000-0003-2078-2196
SPIN-code: 8066-7721

lecturer at the Infectious Diseases (with a course in Medical Parasitology and Tropical Diseases) Department

Russian Federation, Saint Petersburg

Igor M. Yurkaev

Military Medical Academy

Email: igor.yurkaev@yandex.ru
SPIN-code: 4664-1850

M.D., Ph.D. (Medicine), Associate Professor of Infectious Diseases (with a course in Medical Parasitology and Tropical Diseases) Department

Russian Federation, Saint Petersburg

References

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