Stopping intra-abdominal bleeding with promising local biocompatible hemostatic agents

BACKGROUND: In this study, for the first time, an experimental evaluation of the effectiveness of samples of a new local biocompatible hemostatic agent in the form of a gel based on chitosan was carried out with ongoing intra-abdominal bleeding.

AIM: to evaluate the effectiveness of promising local biocompatible hemostatic agents for ongoing intra-abdominal bleeding in an experiment using biological objects.

MATERIALS AND METHODS: When performing this work, an experimental model was developed on biological objects (rabbits) to evaluate the effectiveness of hemostatic agents in the form of a gel with continued bleeding from a liver wound.

RESULTS: During the experiment, the high efficiency of new LBHA samples was established, which allowed to avoid mortality in comparison with the control group, where the mortality rate was 100%.

CONCLUSION: The developed experimental model, which includes injury to the liver with the subsequent development of intense intra-abdominal bleeding, has fully justified itself. The use of local biocompatible hemostatic agents in the form of a gel is a promising way to achieve hemostasis in the early stages of medical evacuation for abdominal injuries, which in turn has the potential to significantly reduce the number of deaths caused by ongoing intra-abdominal bleeding. The data obtained, indicating the high efficiency of individual samples, make it possible to consider the continuation of research in this direction appropriate. Further evaluation of the efficacy and safety of local biocompatible hemostatic agents requires additional studies on medium and large biological objects with all the samples presented to determine their effect on the body, biocompatibility, as well as local irritant action.