Disorder of the intestinal microbial tissue complex after a new coronavirus infection as an interdisciplinary problem
- Authors: Grigorovich M.S.1
-
Affiliations:
- Kirov State Medical University
- Issue: Vol 26, No 1 (2022)
- Pages: 33-40
- Section: Case report
- URL: https://journals.rcsi.science/RFD/article/view/101087
- DOI: https://doi.org/10.17816/RFD101087
- ID: 101087
Cite item
Abstract
The occurrence of diarrhea in comorbid patients with COVID-19 infection against the background of microbiocenosis disorders may be a factor in the worse outcome of the disease. The biggest threat posed by diarrhea is dehydration. Evaluation, control and timely correction of disorders of the gastrointestinal tract, allowing to identify signs associated with dehydration, impaired water and electrolyte balance, intestinal microecology and phenomena of increased epithelial permeability. It is important to consider the risk of diarrhea in patients undergoing massive therapy for COVID-19.
On the example of a specific clinical case, the most common mistakes in managing patients with acute/persistent diarrhea are analyzed. The tactics of managing a patient with diarrheal syndrome after a COVID-19 infection has been defined and substantiated, the importance of a holistic approach to solving patient problems from the standpoint of the “one health” concept has been substantiated.
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##article.viewOnOriginalSite##About the authors
Marina S. Grigorovich
Kirov State Medical University
Author for correspondence.
Email: grigorovich-mari@mail.ru
SPIN-code: 7488-0422
MD, Dr. Sci. (Med.), Assistant Professor
Russian Federation, KirovReferences
- Xiao F, Tang M, Zheng X, et al. Evidence for gastrointestinal infection of SARS-CoV-2. Gastroenterology. 2020;158(6):1831–1833. doi: 10.1053/j.gastro.2020.02.055
- Cheung KS, Hung IF, Chan PP, et al. Gastrointestinal manifestations of SARS-CoV-2 infection and virus load in fecal samples from the Hong Kong cohort and systematic review and meta-analysis. Gastroenterology. 2020;159(1):81–95. doi: 10.1053/j.gastro.2020.03.065
- Hoffmann M, Kleine-Weber H, Schroeder S, et al. SARSCoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020;181(2):271–280e8. doi: 10.1016/j.cell.2020.02.052
- Grinevich VB, Gubonina IV, Doshchitsin VL, et al. Management of patients with comorbidity during novel coronavirus (COVID-19) pandemic. National Consensus Statement 2020. Cardiovascular Therapy and Prevention. 2020;19(4):2630. (In Russ.). doi: 10.15829/1728-8800-2020-2630
- Grinevich VB, Kravchuk YuA, Ped VI, et al. Management of patients with digestive diseases during the COVID-19 pandemic. Clinical Practice Guidelines by the Russian scientific medical society of internal medicine (RSMSIM) and the Gastroenterological Scientific Society of Russia (2nd edition). Experimental and Clinical Gastroenterology. 2021;(3):5–82. (In Russ.) doi: 10.31146/1682-8658-ecg-187-3-5-82
- Maslennikov R, Svistunov A, Ivashkin V, et al. Early viral versus late antibiotic-associated diarrhea in novel coronavirus infection. Medicine (Baltimore). 2021;100(41):e27528. doi: 10.1097/MD.0000000000027528
- Giannelli FR. Antibiotic-associated diarrhea. JAAPA. 2017;30(10):46–47. doi: 10.1097/01.JAA.0000524721.01579.c9
- Osadchuk MA, Svistunov AA. Antibiotic-associated diarrhea in clinical practice. Current Pediatrics. 2014;13(1):102–108. (In Russ.). doi: 10.15690/vsp.v13i1.918
- Shlyapnikov SA, Naser NR, Batyrshin IM, et al. Theantibiotic-associated colitis is a newproblem in surgery. Bulletin of Pirogov National Medical and Surgical Center. 2020;15:138–143.(In Russ.). doi: 10.25881/BPNMSC.2020.62.96.024
- Francino MP. Antibiotics and the human gut microbiome: dysbioses and accumulation of resistances. Front Microbiol. 2016;6:1543. doi: 10.3389/fmicb.2015.01543
- Shelygin Yu, Alyoshkin V, Suhina M, et al. Clinical recommendations of the national association of specialists for the healthcare-related infections control and the Russian association of coloproctology on diagnosis, treatment and prophylaxis of clostridium difficile-associated diarrhea (CDI). Koloproktologiya. 2018;(3):7–23. (In Russ.). doi: 10.33878/2073-7556-2018-0-3-7-23
- Ivashkin VT, Yushchuk ND, Mayev IV, et al. Diagnostics and treatment of Clostridium difficile-associated disease: Guidelines of the Russian gastroenterological association. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2016;26(5). (In Russ.)
- Gu S, Chen Y, Wu Z, et al. Alterations of the gut microbiota in patients with coronavirus disease 2019 orH1N1 influenza. Clin Infect Dis. 2020;71(10):2669–2678. doi: 10.1093/cid/ciaa709
- Simanenkov VI, Maev IV, Tkacheva ON, et al. Syndrome of increased epithelial permeability in clinical practice. Multidisciplinary national Consensus. Cardiovascular Therapy and Prevention. 2021;20(1):2758. (In Russ.). doi: 10.15829/1728-8800-2021-2758
- Korneva EA. Pathways of neuro-immune communication: past and present time, clinical application. Medical Immunology (Russia). 2020;22(3):405–418. (In Russ.). doi: 10.15789/1563-0625-PON-1974
- Wouters MM, Van Wanrooy S, Nguyen A, et al. Psychological comorbidity increases the risk for postinfectious IBS partly by enhanced susceptibility to develop infectious gastroenteritis. Gut. 2016;65(8):1279–1288. doi: 10.1136/gutjnl-2015-309460
- Molina-Torres G, Rodriguez-Arrastia M, Roman P, et al. Stress and the gut microbiota-brain axis. Behav Pharmacol. 2019;30(2 and 3-Spec Issue):187–200. doi: 10.1097/FBP.0000000000000478
- Zuo T, Zhang F, Lui GCY, et al. Alterations in gut microbiota of patients with COVID-19 during time of hospitalization. Gastroenterology. 2020;159(3):944–955.e8. doi: 10.1053/j.gastro.2020.05.048
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