Emerging techniques in atherosclerosis imaging

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Abstract

Atherosclerosis is a chronic immunomodulated disease that affects multiple vascular beds and results in a significant worldwide disease burden. Conventional imaging modalities focus on the morphological features of atherosclerotic disease such as the degree of stenosis caused by a lesion. Modern CT, MR and positron emission tomography scanners have seen significant improvements in the rapidity of image acquisition and spatial resolution. This has increased the scope for the clinical application of these modalities. Multimodality imaging can improve cardiovascular risk prediction by informing on the constituency and metabolic processes within the vessel wall. Specific disease processes can be targeted using novel biological tracers and “smart” contrast agents. These approaches have the potential to inform clinicians of the metabolic state of atherosclerotic plaque.

This review will provide an overview of current imaging techniques for the imaging of atherosclerosis and how various modalities can provide information that enhances the depiction of basic morphology.

This publication is the reprint with Russian translation from original: Syed MB, Fletcher AJ, Forsythe RO, Kaczynski J, Newby DE, Dweck MR, van Beek EJ. Emerging techniques in atherosclerosis imaging. Br J Radiol. 2019;92(1103):20180309. doi: 10.1259/bjr.20180309.

About the authors

Maaz B.J. Syed

University of Edinburgh

Email: maaz.syed@ed.ac.uk
ORCID iD: 0000-0003-0530-8306
United Kingdom, 49 Little France Crescent, Edinburgh EH16 4SB

Alexander J. Fletcher

University of Edinburgh

Email: maaz.syed@ed.ac.uk
ORCID iD: 0000-0001-9984-8391
United Kingdom, 49 Little France Crescent, Edinburgh EH16 4SB

Rachael O. Forsythe

University of Edinburgh

Email: maaz.syed@ed.ac.uk
ORCID iD: 0000-0002-3311-9599
United Kingdom, 49 Little France Crescent, Edinburgh EH16 4SB

Jakub Kaczynski

University of Edinburgh

Email: maaz.syed@ed.ac.uk
ORCID iD: 0000-0002-3005-6860
United Kingdom, 49 Little France Crescent, Edinburgh EH16 4SB

David E. Newby

University of Edinburgh

Email: maaz.syed@ed.ac.uk
ORCID iD: 0000-0001-7971-4628
United Kingdom, 49 Little France Crescent, Edinburgh EH16 4SB

Marc R. Dweck

University of Edinburgh

Email: maaz.syed@ed.ac.uk
ORCID iD: 0000-0001-9847-5917
United Kingdom, 49 Little France Crescent, Edinburgh EH16 4SB

Edwin J. R. van Beek

University of Edinburgh

Author for correspondence.
Email: maaz.syed@ed.ac.uk
ORCID iD: 0000-0002-2777-5071
United Kingdom, Эдинбург 49 Little France Crescent, Edinburgh EH16 4SB

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Supplementary files

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2. Fig. 2. Imaging of coronary atherosclerosis in a patient with myocardial infarction without ST segment elevation.

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3. Fig. 3. Computed tomography (CT), magnetic resonance imaging (MRI) and positron emission (PET) tomography in a patient with juxta nal aneurysm of the abdominal aorta.

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4. Fig. 4. 18F-sodium fluoride positron emission tomography and magnetic resonance angiography of symptomatic lesion of the right internal carotid artery.

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Copyright (c) 2021 Syed M.B., Fletcher A.J., Forsythe R.O., Kaczynski J., Newby D.E., Dweck M.R., R. van Beek E.J.

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