The role of computed tomography in the differential diagnosis of an intracardiac mass of the mitral valve: a case series

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Abstract

The differential diagnosis of an echocardiographically detected intracardiac mass in the mitral annulus can be challenging and usually requires a multimodal approach. This type of lesion is very often associated with subvalvular calcification of the mitral valve. The rare, caseous, variant is the most difficult to diagnose. This case series highlights the clinical significance of computed tomography in detecting and characterizing subvalvular mitral annular calcification when other modalities, particularly echocardiography, are inconclusive. The aim of this article was to raise awareness among specialists of the classic signs of caseous subvalvular calcification of the mitral annulus when visualized with different modalities. Special attention is also given to providing a differential diagnostic series that identifies features that differentiate subvalvular calcification of the mitral annulus from other conditions at this site. Healthcare professionals need to be aware of these mitral valve lesions in order to predict possible associated complications and plan a treatment strategy that may help avoid unnecessary surgical procedures in some cases.

About the authors

Maria V. Onoyko

Lomonosov Moscow State University

Author for correspondence.
Email: onoykomary@gmail.com
ORCID iD: 0000-0002-7727-3360
SPIN-code: 6380-7495

MD

Russian Federation, Moscow

Elena A. Mershina

Lomonosov Moscow State University

Email: elena_mershina@mail.ru
ORCID iD: 0000-0002-1266-4926
SPIN-code: 6897-9641

MD, Cand. Sci. (Medicine), Assistant Professor

Russian Federation, Moscow

Amalia A. Arakelyants

Lomonosov Moscow State University; Sechenov First Moscow State Medical University

Email: nxrrimma@mail.ru
ORCID iD: 0000-0002-1243-2471
SPIN-code: 4990-6008

MD, Cand. Sci. (Medicine)

Russian Federation, Moscow

Valentin E. Sinitsyn

Lomonosov Moscow State University

Email: vsini@mail.ru
ORCID iD: 0000-0002-5649-2193
SPIN-code: 8449-6590

MD, Dr. Sci. (Medicine), Professor

Russian Federation, Moscow

References

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Supplementary files

Supplementary Files
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2. 1. Transthoracic echocardiography, B-mode — clinical case 1: a–c — volumetric formation in the posterior flap of the mitral valve; d — signs of mitral regurgitation during Dopplerography; a — parasternal access, long axis of the left ventricle; b — apical four-chamber position; c — parasternal access, short axis on mitral valve level; d — apical two-chamber position.

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3. Fig. 2. Computed tomography of the heart with ECG synchronization - clinical case 1: a—c – with contrast enhancement in the "bone window"; d — without contrast in the "soft tissue window"; subcarvular caseous calcification of the posterior mitral valve: a — three—chamber view; b —four-chamber view; c — image along the short axis at the level of the mitral valve; d is the axial projection.

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4. 3. Computed tomography of the heart with ECG synchronization - clinical case 2: a—c – with contrast enhancement in the "bone window"; d — without contrast in the "soft tissue window"; subcarvular caseous calcification of the posterior mitral valve leaflet: a — four—chamber view; b — two-chamber view along the long axis of the left ventricle; c is the image along the short axis at the level of the mitral valve; d is the axial projection.

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5. 4. Clinical case 3: a–c — magnetic resonance imaging of the heart; d — computed tomography of the heart with ECG synchronization; green arrows - formation in the posterior flap of the mitral valve in a patient with transmural postinfarction scar in the lower wall of the left ventricle at the level of the basal and middle sections (red arrows); a–b — SSFP (Steady-State Free Precession) sequences, two-chamber view along the long axis of the left ventricle, without contrast; c — T1-weighted image with suppression of the signal from the myocardium and delayed contrast enhancement, two-chamber view along the long axis of the left ventricle; d — axial projection, "bone window".

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