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Calcium-ion binding by polymeric alendronate derivatives
- Authors: Nekrasova T.N.1, Fischer A.I.1, Nazarova O.V.1, Salikova E.P.1, Zolotova Y.I.1, Gavrilova I.I.1, Dobrodumov A.V.1, Bezrukova M.A.1, Panarin E.F.1
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Affiliations:
- NRC “Kurchatov Institute” – PNPI – IMC, 199004 Saint-Petersburg, Russian Federation
- Issue: Vol 521, No 1 (2025)
- Pages: 20-24
- Section: CHEMISTRY
- URL: https://journals.rcsi.science/2686-9535/article/view/306146
- DOI: https://doi.org/10.7868/S3034511125020035
- EDN: https://elibrary.ru/iozjfj
- ID: 306146
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Abstract
Water-soluble phosphorus-containing polymers of various structures have been synthesized for the first time: a homopolymer of acryloyl alendronate, its copolymers with 4-acryloylmorpholine and 2-deoxy-2-methacrylamido-D-glucose, and a copolymer of N-vinylpyrrolidone with allyl alendronate. A comparative study of their ability to bind calcium ions has been conducted. It has been shown that for alendronate-containing polymers, the amount of Ca2+ bound by one phosphorus-containing group is 2 to 3 times higher than that of polyvinylphosphonic acid.
Keywords
About the authors
T. N. Nekrasova
NRC “Kurchatov Institute” – PNPI – IMC, 199004 Saint-Petersburg, Russian Federation
Author for correspondence.
Email: nazaro@hq.macro.ru
A. I. Fischer
NRC “Kurchatov Institute” – PNPI – IMC, 199004 Saint-Petersburg, Russian Federation
Email: nazaro@hq.macro.ru
O. V. Nazarova
NRC “Kurchatov Institute” – PNPI – IMC, 199004 Saint-Petersburg, Russian Federation
Email: nazaro@hq.macro.ru
E. P. Salikova
NRC “Kurchatov Institute” – PNPI – IMC, 199004 Saint-Petersburg, Russian Federation
Email: nazaro@hq.macro.ru
Yu. I. Zolotova
NRC “Kurchatov Institute” – PNPI – IMC, 199004 Saint-Petersburg, Russian Federation
Email: nazaro@hq.macro.ru
I. I. Gavrilova
NRC “Kurchatov Institute” – PNPI – IMC, 199004 Saint-Petersburg, Russian Federation
Email: nazaro@hq.macro.ru
A. V. Dobrodumov
NRC “Kurchatov Institute” – PNPI – IMC, 199004 Saint-Petersburg, Russian Federation
Email: nazaro@hq.macro.ru
M. A. Bezrukova
NRC “Kurchatov Institute” – PNPI – IMC, 199004 Saint-Petersburg, Russian Federation
Email: nazaro@hq.macro.ru
E. F. Panarin
NRC “Kurchatov Institute” – PNPI – IMC, 199004 Saint-Petersburg, Russian Federation
Email: nazaro@hq.macro.ru
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Note
In the print version, the article was published under the DOI: 10.31857/S2686953525020035