CHIRAL N-(OCTAHYDRO-2H-CHROMEN-4-YL)-2-(DIALKYLAMINO)ACETAMIDES: SYNTHESIS AND ANALGESIC ACTIVITY
- 作者: Li-Zhulanov N.1, Nikolaichuk K.1,2, Gatilov Y.1, Volcho K.1, Khvostov M.1, Tolstikova T.1, Salakhutdinov N.1
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隶属关系:
- N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of Siberian Branch of Russian Academy of Sciences
- Novosibirsk State University
- 期: 卷 512, 编号 1 (2023)
- 页面: 32-38
- 栏目: ХИМИЯ
- URL: https://journals.rcsi.science/2686-9535/article/view/247178
- DOI: https://doi.org/10.31857/S2686953522600751
- EDN: https://elibrary.ru/UYUMVC
- ID: 247178
如何引用文章
详细
Based on monoterpenoid (–)-isopulegol a number of new derivatives of octahydro-2H-chromene have been synthesized. The structure of the products obtained was determined by 1H and 13C NMR spectroscopy, high resolution mass spectrometry and X-ray diffraction analysis. It was shown that several synthesized compounds exhibit high analgesic activity in in vivo tests. The highest efficiency in both tests (acetic writhing and hot plate) was shown by (4S)-diastereomers of morpholinoacetamide derivatives of octahydro-2H-chromene.
作者简介
N. Li-Zhulanov
N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of Siberian Branch of Russian Academy of Sciences
Email: volcho@nioch.nsc.ru
Russian Federation, 630090, Novosibirsk
K. Nikolaichuk
N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of Siberian Branch of Russian Academy of Sciences; Novosibirsk State University
Email: volcho@nioch.nsc.ru
Russian Federation, 630090, Novosibirsk; Russian Federation, 630090, Novosibirsk
Yu. Gatilov
N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of Siberian Branch of Russian Academy of Sciences
Email: volcho@nioch.nsc.ru
Russian Federation, 630090, Novosibirsk
K. Volcho
N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of Siberian Branch of Russian Academy of Sciences
编辑信件的主要联系方式.
Email: volcho@nioch.nsc.ru
Russian Federation, 630090, Novosibirsk
M. Khvostov
N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of Siberian Branch of Russian Academy of Sciences
Email: volcho@nioch.nsc.ru
Russian Federation, 630090, Novosibirsk
T. Tolstikova
N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of Siberian Branch of Russian Academy of Sciences
Email: volcho@nioch.nsc.ru
Russian Federation, 630090, Novosibirsk
N. Salakhutdinov
N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of Siberian Branch of Russian Academy of Sciences
Email: volcho@nioch.nsc.ru
Russian Federation, 630090, Novosibirsk
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