CITRUS PECTIN COMPLEXES WITH NIFEDIPINE: PREPARATION AND PHYSICOCHEMICAL PROPERTIES

S. T. Minzanova; Минзанова С. Т.; E. V. Chekunkov; Чекунков Е. В.; A. V. Khabibullina; Хабибуллина А. В.; D. M. Arkhipova; Архипова Д. М.; L. G. Mironova; Миронова Л. Г.; A. R. Hamatgalimov; Хаматгалимов А. Р.; V. A. Milyukov; Милюков В. А.; V. F. Mironov; Миронов В. Ф.

doi:10.31857/S2686953523700176

CITRUS PECTIN COMPLEXES WITH NIFEDIPINE: PREPARATION AND PHYSICOCHEMICAL PROPERTIES

Autores: Minzanova S.T.¹, Chekunkov E.V.¹, Khabibullina A.V.¹, Arkhipova D.M.¹, Mironova L.G.¹, Hamatgalimov A.R.¹, Milyukov V.A.¹, Mironov V.F.¹
Afiliações:
1. Arbuzov Institute of Organic and Physical Chemistry, “Kazan Scientific Center of Russian Academy of Sciences”
Edição: Volume 508, Nº 1 (2023)
Páginas: 103-110
Seção: PHYSICAL CHEMISTRY
URL: https://journals.rcsi.science/2686-9535/article/view/135971
DOI: https://doi.org/10.31857/S2686953523700176
EDN: https://elibrary.ru/EWGPLY
ID: 135971

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Resumo

The formation of stable complexes of pectin polysaccharides with the hypotensive drug “Nifedipine” was confirmed by IR and UV spectroscopy, their stoichiometry was determined and the conditions of their production were optimized. Peculiarities of thermal decomposition of pectin and synthesized complexes with nifedipine were studied by TGA/DSC method. The results obtained are a scientific basis for the creation of a new water-soluble non-toxic dosage form of nifedipine, which will significantly expand the use of the drug in medicine.

Palavras-chave

citrus pectin, nifedipine, complexation, complexes, TGA/DSC

Bibliografia

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