INTERACTION OF 2-AMINO-(4-ARYL)-SUBSTITUTED THIA- AND OXAZOLES WITH 5-CYANO-1,2,4-TRIAZINES

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Тек жазылушылар үшін

Аннотация

An interaction of 6-aryl-1,2,4-triazine-5-carbonitriles with 2‑amino-substituted thiazoles and oxazoles has been studied. The difference in the reactivity of these aminoheterocycles depending on the presence of an oxygen or sulfur atom in their composition has been demonstrated. Previously, the 4-aryl-3-hydroxy-2,2'-bipyridines were obtained as products of aza-Diels–Alder reaction between 6-aryl-3-(2-pyridyl)-1,2,4-triazine-5-carbonitriles and 2-amino-4-aryloxazoles. In the present work we have shown that the reaction of 6-aryl-1,2,4-triazine-5-carbonitriles with 2-aminothiazoles led to the products of ipso-substitution of cyano-group. The aza-Diels–Alder reaction of these compounds with 2,5-norbornadiene allowed to obtain (2,2'-bi)pyridines with the thiazol-2-amine moiety at alpha-position.

Авторлар туралы

A. Krinochkin

Ural Federal University; I.Ya. Postovsky Institute of Organic Synthesis of the Ural Branch of the Russian Academy of Sciences

Email: iaroslav.shtaits@urfu.ru
Russian, 620002, Yekaterinburg; Russian, 620219, Yekaterinburg

A. Rammohan

Ural Federal University

Email: iaroslav.shtaits@urfu.ru
Russian, 620002, Yekaterinburg

Ya. Shtaitz

Ural Federal University

Хат алмасуға жауапты Автор.
Email: iaroslav.shtaits@urfu.ru
Russian, 620002, Yekaterinburg

D. Kopchuk

Ural Federal University; I.Ya. Postovsky Institute of Organic Synthesis of the Ural Branch of the Russian Academy of Sciences

Email: iaroslav.shtaits@urfu.ru
Russian, 620002, Yekaterinburg; Russian, 620219, Yekaterinburg

E. Ladin

Ural Federal University

Email: iaroslav.shtaits@urfu.ru
Russian, 620002, Yekaterinburg

E. Sharafieva

Ural Federal University; Ural State Medical University, Ministry of Healthcare of the Russian Federation

Email: iaroslav.shtaits@urfu.ru
Russian, 620002, Yekaterinburg; Russian, 620028, Yekaterinburg

O. Taniya

Ural Federal University; I.Ya. Postovsky Institute of Organic Synthesis of the Ural Branch of the Russian Academy of Sciences

Email: iaroslav.shtaits@urfu.ru
Russian, 620002, Yekaterinburg; Russian, 620219, Yekaterinburg

G. Zyryanov

Ural Federal University; I.Ya. Postovsky Institute of Organic Synthesis of the Ural Branch of the Russian Academy of Sciences

Email: iaroslav.shtaits@urfu.ru
Russian, 620002, Yekaterinburg; Russian, 620219, Yekaterinburg

A. Matern

Ural Federal University

Email: iaroslav.shtaits@urfu.ru
Russian, 620002, Yekaterinburg

O. Chupakhin

Ural Federal University; I.Ya. Postovsky Institute of Organic Synthesis of the Ural Branch of the Russian Academy of Sciences

Email: iaroslav.shtaits@urfu.ru
Russian, 620002, Yekaterinburg; Russian, 620219, Yekaterinburg

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© А.П. Криночкин, А. Раммохан, Я.К. Штайц, Д.С. Копчук, Е.Д. Ладин, Э.Р. Шарафиева, О.С. Тания, Г.В. Зырянов, А.И. Матерн, О.Н. Чупахин, 2023

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