Enviar artigo por via de e-mail EFFECT OF PEGYLATED GRAPHENE OXIDE NANOPARTICLES ON THE METABOLISM OF JURKAT CELLS
- Autores: Timganova V.1, Vlasova V.1, Bochkova M.1,2, Shardina K.1, Uzhviyuk S.1, Khramtsov P.1,2, Rayev M.1,2, Zamorina S.1,2
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Afiliações:
- Institute of Ecology and Genetics of Microorganisms, Perm Federal Research Center of the Ural Branch of the Russian Academy of Sciences
- Perm State National Research University
- Edição: Volume 512, Nº 1 (2023)
- Páginas: 470-473
- Seção: Articles
- URL: https://journals.rcsi.science/2686-7389/article/view/140859
- DOI: https://doi.org/10.31857/S2686738923600292
- EDN: https://elibrary.ru/TASLVY
- ID: 140859
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Resumo
The effect of graphene oxide (GO) nanoparticles of 100–200 nm size coated with linear (LP-GO) and branched (BP-GO) polyethylene glycol at concentrations of 5 and 25 μg/mL on the metabolism of Jurkat tumor cells was studied. It was found that LP-GO nanoparticles at a concentration of 25 μg/mL can enhance basal glycolysis of Jurkat T lymphocyte tumor cell line cells, while LP-GO and BP-GO at the same concentration can reduce the indicators of compensatory glycolysis. Despite this, GO nanoparticles coated with linear and branched PEG at a concentration of 5 μg/mL do not have pronounced effects on oxidative phosphorylation and glycolysis of Jurkat cells and could therefore be safe for activated T cells.
Sobre autores
V. Timganova
Institute of Ecology and Genetics of Microorganisms, Perm Federal Research Center of the Ural Branchof the Russian Academy of Sciences
Autor responsável pela correspondência
Email: timganovavp@gmail.com
Russian Federation, Perm
V. Vlasova
Institute of Ecology and Genetics of Microorganisms, Perm Federal Research Center of the Ural Branchof the Russian Academy of Sciences
Email: timganovavp@gmail.com
Russian Federation, Perm
M. Bochkova
Institute of Ecology and Genetics of Microorganisms, Perm Federal Research Center of the Ural Branchof the Russian Academy of Sciences; Perm State National Research University
Email: timganovavp@gmail.com
Russian Federation, Perm; Russian Federation, Perm
K. Shardina
Institute of Ecology and Genetics of Microorganisms, Perm Federal Research Center of the Ural Branchof the Russian Academy of Sciences
Email: timganovavp@gmail.com
Russian Federation, Perm
S. Uzhviyuk
Institute of Ecology and Genetics of Microorganisms, Perm Federal Research Center of the Ural Branchof the Russian Academy of Sciences
Email: timganovavp@gmail.com
Russian Federation, Perm
P. Khramtsov
Institute of Ecology and Genetics of Microorganisms, Perm Federal Research Center of the Ural Branchof the Russian Academy of Sciences; Perm State National Research University
Email: timganovavp@gmail.com
Russian Federation, Perm; Russian Federation, Perm
M. Rayev
Institute of Ecology and Genetics of Microorganisms, Perm Federal Research Center of the Ural Branchof the Russian Academy of Sciences; Perm State National Research University
Email: timganovavp@gmail.com
Russian Federation, Perm; Russian Federation, Perm
S. Zamorina
Institute of Ecology and Genetics of Microorganisms, Perm Federal Research Center of the Ural Branchof the Russian Academy of Sciences; Perm State National Research University
Email: timganovavp@gmail.com
Russian Federation, Perm; Russian Federation, Perm
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