SYNTHESIS OF 1-[ω-(BROMOPHENOXY)ALKYL]-3-NAPHTHALENYLMETHYL DERIVATIVES OF URACIL AND THEIR ANALOGUES AS PROBABLE INHIBITORS OF HUMAN CYTOMEGALOVIRUS REPLICATION

M. P. Paramonova; Парамонова М. П.; E. S. Gureeva; Гуреева Е. С.; A. A. Ozerova; Озеров А. А.; R. Snoeck; Snoeck R.; G. Andrei; Andrei G.; D. A. Alexandrov; Александров Д. А.; A. L. Khandazhinskaya; Хандажинская А. Л.; M. S. Novikova; Новиков М. С.; S. N. Kochetkov; Кочетков С. Н.

doi:10.31857/S2686738922700044

SYNTHESIS OF 1-[ω-(BROMOPHENOXY)ALKYL]-3-NAPHTHALENYLMETHYL DERIVATIVES OF URACIL AND THEIR ANALOGUES AS PROBABLE INHIBITORS OF HUMAN CYTOMEGALOVIRUS REPLICATION

Autores: Paramonova M.¹, Gureeva E.¹, Ozerova A.¹, Snoeck R.², Andrei G.², Alexandrov D.³, Khandazhinskaya A.⁴, Novikova M.¹, Kochetkov S.⁴
Afiliações:
1. Volgograd State Medical University
2. Rega Institute for Medical Research, KU Leuven
3. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
4. V.A. Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences
Edição: Volume 508, Nº 1 (2023)
Páginas: 35-40
Seção: Articles
URL: https://journals.rcsi.science/2686-7389/article/view/135669
DOI: https://doi.org/10.31857/S2686738922700044
EDN: https://elibrary.ru/MJOYWY
ID: 135669

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Resumo

A new series of 1-[ω-(bromophenoxy) has been synthesizedalkyl]-uracil derivatives containing naphthalene-1-yl-, naphthalene-2-yl-, 1-brominaphthalene-2-ilmethyl, benzyl and anthracene-9-ilmethyl fragments in position 3 of uracil. Antiviral properties of synthesized compounds against human cytomegalovirus were studied. It was found that the compound, which has a bridge consisting of five methylene groups, has high anti-cytomegalovirus activity in vitro. uracil

Palavras-chave

derivatives, synthesis, antiviral activity, human cytomegalovirus

Sobre autores

M. Paramonova

Volgograd State Medical University

Email: khandazhinskaya@bk.ru
Russian Federation, Volgograd

E. Gureeva

Volgograd State Medical University

Email: khandazhinskaya@bk.ru
Russian Federation, Volgograd

A. Ozerova

Volgograd State Medical University

Email: khandazhinskaya@bk.ru
Russian Federation, Volgograd

R. Snoeck

Rega Institute for Medical Research, KU Leuven

Email: khandazhinskaya@bk.ru
Belgium, B-3000, Leuven, Herestraat 49 bus 1043

G. Andrei

Rega Institute for Medical Research, KU Leuven

Email: khandazhinskaya@bk.ru
Belgium, B-3000, Leuven, Herestraat 49 bus 1043

D. Alexandrov

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences

Email: khandazhinskaya@bk.ru
Russian Federation, Moscow

A. Khandazhinskaya

V.A. Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences

Autor responsável pela correspondência
Email: khandazhinskaya@bk.ru
Russian Federation, Moscow

M. Novikova

Volgograd State Medical University

Email: khandazhinskaya@bk.ru
Russian Federation, Volgograd

S. Kochetkov

V.A. Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences

Email: khandazhinskaya@bk.ru
Russian Federation, Moscow

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