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SYNTHESIS OF 1-[ω-(BROMOPHENOXY)ALKYL]-3-NAPHTHALENYLMETHYL DERIVATIVES OF URACIL AND THEIR ANALOGUES AS PROBABLE INHIBITORS OF HUMAN CYTOMEGALOVIRUS REPLICATION
- Authors: Paramonova M.P.1, Gureeva E.S.1, Ozerova A.A.1, Snoeck R.2, Andrei G.2, Alexandrov D.A.3, Khandazhinskaya A.L.4, Novikova M.S.1, Kochetkov S.N.4
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Affiliations:
- Volgograd State Medical University
- Rega Institute for Medical Research, KU Leuven
- Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
- V.A. Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences
- Issue: Vol 508, No 1 (2023)
- Pages: 35-40
- Section: Articles
- URL: https://journals.rcsi.science/2686-7389/article/view/135669
- DOI: https://doi.org/10.31857/S2686738922700044
- EDN: https://elibrary.ru/MJOYWY
- ID: 135669
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Abstract
A new series of 1-[ω-(bromophenoxy) has been synthesizedalkyl]-uracil derivatives containing naphthalene-1-yl-, naphthalene-2-yl-, 1-brominaphthalene-2-ilmethyl, benzyl and anthracene-9-ilmethyl fragments in position 3 of uracil. Antiviral properties of synthesized compounds against human cytomegalovirus were studied. It was found that the compound, which has a bridge consisting of five methylene groups, has high anti-cytomegalovirus activity in vitro. uracil
Keywords
About the authors
M. P. Paramonova
Volgograd State Medical University
Email: khandazhinskaya@bk.ru
Russian Federation, Volgograd
E. S. Gureeva
Volgograd State Medical University
Email: khandazhinskaya@bk.ru
Russian Federation, Volgograd
A. A. Ozerova
Volgograd State Medical University
Email: khandazhinskaya@bk.ru
Russian Federation, Volgograd
R. Snoeck
Rega Institute for Medical Research, KU Leuven
Email: khandazhinskaya@bk.ru
Belgium, B-3000, Leuven, Herestraat 49 bus 1043
G. Andrei
Rega Institute for Medical Research, KU Leuven
Email: khandazhinskaya@bk.ru
Belgium, B-3000, Leuven, Herestraat 49 bus 1043
D. A. Alexandrov
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Email: khandazhinskaya@bk.ru
Russian Federation, Moscow
A. L. Khandazhinskaya
V.A. Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences
Author for correspondence.
Email: khandazhinskaya@bk.ru
Russian Federation, Moscow
M. S. Novikova
Volgograd State Medical University
Email: khandazhinskaya@bk.ru
Russian Federation, Volgograd
S. N. Kochetkov
V.A. Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences
Email: khandazhinskaya@bk.ru
Russian Federation, Moscow
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