DIFFERENT PROTEIN GROUPS INVOLVED IN TRANSCRIPTION REGULATION IN GENES OF DEVELOPMENT AND HOUSEKEEPING IN DROSOPHILA

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Тек жазылушылар үшін

Аннотация

Antibodies to histone modifications and an insulator protein involved in the processes of transcription initiation and elongation are mapped in Drosophila polytene chromosomes. The CHRIZ protein (chromatin insulator) and H3K36me3 histone modification (RNA elongation) are detected only in the localization of housekeeping genes (interbands and gray bands of polytene chromosomes) and never in the regions of development genes (black bands and large puffs arising from them). Antibodies to H3S10P histone modification, which is associated with the initial elongation of the RNA strand during transcription, are found exclusively in small puffs, but not in housekeeping gene localization sites or large ecdysone-induced puffs, where housekeeping genes are localized. Antibodies to H4R3me2 histone modification (a co-repressor of the ecdysone receptor) are detected only in large α-induced puffs.

Авторлар туралы

I. Zhimulev

Institute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences

Хат алмасуға жауапты Автор.
Email: zhimulev@mcb.nsc.ru
Russian Federation, Novosibirsk

T. Vatolina

Institute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences

Email: zhimulev@mcb.nsc.ru
Russian Federation, Novosibirsk

G. Pokholkova

Institute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences

Email: zhimulev@mcb.nsc.ru
Russian Federation, Novosibirsk

O. Antonenko

Institute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences

Email: zhimulev@mcb.nsc.ru
Russian Federation, Novosibirsk

M. Maltseva

Institute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences

Email: zhimulev@mcb.nsc.ru
Russian Federation, Novosibirsk

Әдебиет тізімі

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