THE XMAS-2 PROTEIN OF DROSOPHILA MELANOGASTER UNDERGOES CLEAVAGE INTO TWO FRAGMENTS
- Авторлар: Kurshakova M.1, Georgieva S.1, Kopytova D.1
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Мекемелер:
- Institute of Molecular Biology, Russian Academy of Sciences
- Шығарылым: Том 509, № 1 (2023)
- Беттер: 166-169
- Бөлім: Articles
- URL: https://journals.rcsi.science/2686-7389/article/view/135642
- DOI: https://doi.org/10.31857/S2686738922700111
- EDN: https://elibrary.ru/NAZLMZ
- ID: 135642
Дәйексөз келтіру
Аннотация
The TREX-2 complex integrates several stages of gene expression, such as transcriptional activation and mRNA export. In D. melanogaster TREX-2 consists of four main proteins: Xmas-2, ENY2, PCID2, and Sem1p. Xmas-2 protein is the core subunit of the complex with which other TREX-2 subunits interact. Xmas-2 homologues have been found in all higher eukaryotes. Previously, it was shown that the human Xmas-2 homologue, GANP protein can undergo cleavage into two parts, probably during apoptotic cell death. We showed that the Xmas-2 protein of D. melanogaster also can split into two fragments. The resulting fragments of the protein correspond to the two large domains of Xmas-2. Protein splitting is observed both in vivo and in vitro. However, Xmas-2 cleavage in D. melanogaster is observed under normal conditions and is probably a part of the mechanism of transcription and mRNA export regulation in D. melanogaster.
Негізгі сөздер
Авторлар туралы
M. Kurshakova
Institute of Molecular Biology, Russian Academy of Sciences
Email: d_dmitrieva@mail.ru
Russian Federation, Moscow
S. Georgieva
Institute of Molecular Biology, Russian Academy of Sciences
Email: d_dmitrieva@mail.ru
Russian Federation, Moscow
D. Kopytova
Institute of Molecular Biology, Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: d_dmitrieva@mail.ru
Russian Federation, Moscow
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