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Development of a panel of biomarkers for differential diagnosis of multiple sclerosis
- Authors: Ovchinnikova L.A.1, Dzhelad S.S.1, Simaniv T.O.2, Zakharova M.N.2, Lomakin Y.A.1, Gabibov A.G.1,3, Illarioshkin S.N.2
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Affiliations:
- Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS
- Research Center of Neurology
- Lomonosov Moscow State University
- Issue: Vol 519, No 1 (2024)
- Pages: 98-102
- Section: Articles
- URL: https://journals.rcsi.science/2686-7389/article/view/274318
- DOI: https://doi.org/10.31857/S2686738924060155
- ID: 274318
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Abstract
Demyelinating diseases are a group of heterogeneous pathologies that affect the nervous system and reduce the quality of life. One such disease is multiple sclerosis (MS), an inflammatory autoimmune neurodegenerative disease of the central nervous system (CNS). At the initial stages, MS can mimic some infectious, neoplastic, genetic, metabolic, vascular and other pathologies. Accurate differential diagnosis of this disease is important to improve the quality of life of patients and reduce possible irreversible damage to the central nervous system. In this work, we confirmed the possibility of using our previously proposed candidate panel of MS biomarkers to distinguish MS from neuromyelitis optica spectrum diseases (NMOSD) and amyotrophic lateral sclerosis (ALS). We have shown that our proposed panel (SPTAN1601-644 + PRX451-494 + PTK6301-344 + LMP1285-330) allows us to distinguish MS from ALS (AUC = 0,796) and NMOSD (AUC = 0,779).
About the authors
L. A. Ovchinnikova
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS
Email: yasha.l@bk.ru
Russian Federation, Moscow
S. S. Dzhelad
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS
Email: yasha.l@bk.ru
Russian Federation, Moscow
T. O. Simaniv
Research Center of Neurology
Email: yasha.l@bk.ru
Russian Federation, Moscow
M. N. Zakharova
Research Center of Neurology
Email: yasha.l@bk.ru
Russian Federation, Moscow
Y. A. Lomakin
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS
Author for correspondence.
Email: yasha.l@bk.ru
Russian Federation, Moscow
A. G. Gabibov
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS; Lomonosov Moscow State University
Email: gabibov@gmail.com
Academician of the RAS
Russian Federation, Moscow; MoscowS. N. Illarioshkin
Research Center of Neurology
Email: yasha.l@bk.ru
Academician of the RAS
Russian Federation, MoscowReferences
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