电邮这篇文章 Development of a panel of biomarkers for differential diagnosis of multiple sclerosis
- 作者: Ovchinnikova L.A.1, Dzhelad S.S.1, Simaniv T.O.2, Zakharova M.N.2, Lomakin Y.A.1, Gabibov A.G.1,3, Illarioshkin S.N.2
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隶属关系:
- Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS
- Research Center of Neurology
- Lomonosov Moscow State University
- 期: 卷 519, 编号 1 (2024)
- 页面: 98-102
- 栏目: Articles
- URL: https://journals.rcsi.science/2686-7389/article/view/274318
- DOI: https://doi.org/10.31857/S2686738924060155
- ID: 274318
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详细
Demyelinating diseases are a group of heterogeneous pathologies that affect the nervous system and reduce the quality of life. One such disease is multiple sclerosis (MS), an inflammatory autoimmune neurodegenerative disease of the central nervous system (CNS). At the initial stages, MS can mimic some infectious, neoplastic, genetic, metabolic, vascular and other pathologies. Accurate differential diagnosis of this disease is important to improve the quality of life of patients and reduce possible irreversible damage to the central nervous system. In this work, we confirmed the possibility of using our previously proposed candidate panel of MS biomarkers to distinguish MS from neuromyelitis optica spectrum diseases (NMOSD) and amyotrophic lateral sclerosis (ALS). We have shown that our proposed panel (SPTAN1601-644 + PRX451-494 + PTK6301-344 + LMP1285-330) allows us to distinguish MS from ALS (AUC = 0,796) and NMOSD (AUC = 0,779).
作者简介
L. Ovchinnikova
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS
Email: yasha.l@bk.ru
俄罗斯联邦, Moscow
S. Dzhelad
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS
Email: yasha.l@bk.ru
俄罗斯联邦, Moscow
T. Simaniv
Research Center of Neurology
Email: yasha.l@bk.ru
俄罗斯联邦, Moscow
M. Zakharova
Research Center of Neurology
Email: yasha.l@bk.ru
俄罗斯联邦, Moscow
Y. Lomakin
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS
编辑信件的主要联系方式.
Email: yasha.l@bk.ru
俄罗斯联邦, Moscow
A. Gabibov
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS; Lomonosov Moscow State University
Email: gabibov@gmail.com
Academician of the RAS
俄罗斯联邦, Moscow; MoscowS. Illarioshkin
Research Center of Neurology
Email: yasha.l@bk.ru
Academician of the RAS
俄罗斯联邦, Moscow参考
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