INCUBATION OF LYMPHOCYTES WITH IL-2 CAUSES THE APPEARANCE OF ANTITUMOR T CELLS CARRYING FC, CD25 AND LFA-1 ON THE SURFACE
- Authors: Ivanova O.K.1, Sharapova T.N.1, Romanova E.A.1, Yashin D.V.1, Sashchenko L.P.1
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Affiliations:
- Institute of Gene Biology of the Russian Academy of Sciences
- Issue: Vol 510, No 1 (2023)
- Pages: 225-230
- Section: Articles
- URL: https://journals.rcsi.science/2686-7389/article/view/135687
- DOI: https://doi.org/10.31857/S2686738923700208
- EDN: https://elibrary.ru/QICODU
- ID: 135687
Cite item
Abstract
To carry out antitumor activity against cells that have lost surface antigens, human lymphocytes must have a certain repertoire of surface proteins capable of contacting a tumor cell and inducing programmed cell death in it. In this work, we showed that activation of healthy donor cells by IL-2 cytokine within 6 days causes the appearance of FasL, CD25 and LFA-1 proteins on CD8+CD25+ T lymphocytes, and also converts the LFA-1 protein into an active form having a high affinity for its target, ICAM-1 integrin. The appearance of these proteins on the surface of this subpopulation of lymphocytes allows them to induce programmed cell death in HLA-negative tumor cells.
Keywords
About the authors
O. K. Ivanova
Institute of Gene Biology of the Russian Academy of Sciences
Author for correspondence.
Email: olga.k.ivanova@gmail.com
Russian Federation, Moscow
T. N. Sharapova
Institute of Gene Biology of the Russian Academy of Sciences
Email: olga.k.ivanova@gmail.com
Russian Federation, Moscow
E. A. Romanova
Institute of Gene Biology of the Russian Academy of Sciences
Email: olga.k.ivanova@gmail.com
Russian Federation, Moscow
D. V. Yashin
Institute of Gene Biology of the Russian Academy of Sciences
Email: olga.k.ivanova@gmail.com
Russian Federation, Moscow
L. P. Sashchenko
Institute of Gene Biology of the Russian Academy of Sciences
Email: olga.k.ivanova@gmail.com
Russian Federation, Moscow
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