INCUBATION OF LYMPHOCYTES WITH IL-2 CAUSES THE APPEARANCE OF ANTITUMOR T CELLS CARRYING FC, CD25 AND LFA-1 ON THE SURFACE

O. K. Ivanova; Иванова О. К.; T. N. Sharapova; Шарапова Т. Н.; E. A. Romanova; Романова Е. А.; D. V. Yashin; Яшин Д. В.; L. P. Sashchenko; Сащенко Л. П.

doi:10.31857/S2686738923700208

INCUBATION OF LYMPHOCYTES WITH IL-2 CAUSES THE APPEARANCE OF ANTITUMOR T CELLS CARRYING FC, CD25 AND LFA-1 ON THE SURFACE

Autores: Ivanova O.¹, Sharapova T.¹, Romanova E.¹, Yashin D.¹, Sashchenko L.¹
Afiliações:
1. Institute of Gene Biology of the Russian Academy of Sciences
Edição: Volume 510, Nº 1 (2023)
Páginas: 225-230
Seção: Articles
URL: https://journals.rcsi.science/2686-7389/article/view/135687
DOI: https://doi.org/10.31857/S2686738923700208
EDN: https://elibrary.ru/QICODU
ID: 135687

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Estatísticas

Resumo

To carry out antitumor activity against cells that have lost surface antigens, human lymphocytes must have a certain repertoire of surface proteins capable of contacting a tumor cell and inducing programmed cell death in it. In this work, we showed that activation of healthy donor cells by IL-2 cytokine within 6 days causes the appearance of FasL, CD25 and LFA-1 proteins on CD8⁺CD25⁺ T lymphocytes, and also converts the LFA-1 protein into an active form having a high affinity for its target, ICAM-1 integrin. The appearance of these proteins on the surface of this subpopulation of lymphocytes allows them to induce programmed cell death in HLA-negative tumor cells.

Palavras-chave

Tag7, integrins, FasL, IL-2, tumor cells

Bibliografia

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