Email this article Assessing the efficacy of anti-cancer drugs on organoid models derived from prostate cancer
- Authors: Silkina M.O.1, Razumovskaya A.V.1, Nikulin S.V.1,2, Tonevitsky A.G.1, Alekseev B.Y.2
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Affiliations:
- National Research University “Higher School of Economics”
- National Medical Research Radiological Center, Ministry of Health of Russia
- Issue: Vol 515, No 1 (2024)
- Pages: 10-13
- Section: Articles
- URL: https://journals.rcsi.science/2686-7389/article/view/262817
- DOI: https://doi.org/10.31857/S2686738924020021
- EDN: https://elibrary.ru/WGAXGU
- ID: 262817
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Abstract
It has been proven that tumor organoids effectively mirror the phenotypic and genetic traits of the original biomaterial. It has been noted that outcomes from drug testing in organoid cultures can accurately represent the clinical response observed in patients. In this study, an organoid culture was derived from biopsy material of prostate cancer (PC). Subsequently, clinical practice drugs, docetaxel and enzalutamide, were tested on this organoid culture. Various techniques for evaluating the efficacy of drugs in vitro were compared. The half maximal inhibitory concentration of docetaxel was found to be markedly lower compared to that of enzalutamide. However, when tested at clinically relevant concentrations and incubation times, enzalutamide was more effective than docetaxel. Therefore, it is crucial to optimize the testing conditions for drugs on in vitro cultures for their subsequent application in clinical practice.
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About the authors
M. O. Silkina
National Research University “Higher School of Economics”
Author for correspondence.
Email: mosilkina@hse.ru
Russian Federation, Moscow
A. V. Razumovskaya
National Research University “Higher School of Economics”
Email: mosilkina@hse.ru
Russian Federation, Moscow
S. V. Nikulin
National Research University “Higher School of Economics”; National Medical Research Radiological Center, Ministry of Health of Russia
Email: mosilkina@hse.ru
Russian Federation, Moscow; Moscow
A. G. Tonevitsky
National Research University “Higher School of Economics”
Email: mosilkina@hse.ru
Russian Federation, Moscow
B. Ya. Alekseev
National Medical Research Radiological Center, Ministry of Health of Russia
Email: mosilkina@hse.ru
Russian Federation, Moscow
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