IN HIV-INFECTED IMMUNOLOGICAL NON-RESPONDERS, HEPATITIS C VIRUS ERADICATION CONTRIBUTES TO INCOMPLETE NORMALIZATION OF SYSTEMIC INFLAMMATION INDEXES, BUT DOES NOT LEAD TO RAPID CD4 +  T-CELL COUNT RECOVERY

E. V. Saidakova; Сайдакова Е. В.; L. B. Korolevskaya; Королевская Л. Б.; N. G. Shmagel; Шмагель Н. Г.; V. V. Vlasova; Власова В. В.; K. Yu. Shardina; Шардина К. Ю.; V. A. Chereshnev; Черешнев В. А.; K. V. Shmagel; Шмагель К. В.

doi:10.31857/S2686738923600243

IN HIV-INFECTED IMMUNOLOGICAL NON-RESPONDERS, HEPATITIS C VIRUS ERADICATION CONTRIBUTES TO INCOMPLETE NORMALIZATION OF SYSTEMIC INFLAMMATION INDEXES, BUT DOES NOT LEAD TO RAPID CD4⁺ T-CELL COUNT RECOVERY

Authors: Saidakova E.V.¹, Korolevskaya L.B.¹, Shmagel N.G.¹, Vlasova V.V.¹, Shardina K.Y.¹, Chereshnev V.A.¹^,2, Shmagel K.V.¹
Affiliations:
1. Perm Federal Research Center Ural Branch Russian Academy of Sciences
2. Institute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences
Issue: Vol 512, No 1 (2023)
Pages: 454-459
Section: Articles
URL: https://journals.rcsi.science/2686-7389/article/view/140852
DOI: https://doi.org/10.31857/S2686738923600243
EDN: https://elibrary.ru/OYAHSW
ID: 140852

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Abstract

In HIV-positive individuals taking antiretroviral therapy, coinfection with hepatitis C virus (HCV) increases the systemic inflammation, which interferes with the CD4⁺ T-cells regeneration. This study evaluated the effect of HCV eradication on systemic inflammation and CD4⁺ T-cell regeneration in patients who gave poor response to antiretroviral therapy, the so-called “immunological non-responders” (INRs). HIV-infected patients who received a course of direct-acting antiviral drugs for treating hepatitis C were examined. The control groups included HIV/HCV-coinfected individuals and relatively healthy volunteers. It has been established for the first time that HCV eradication is not accompanied by a complete suppression of systemic inflammation, but improves the T-cell pool composition: in INRs, the blood CD4⁺/CD8⁺ T-lymphocyte ratio increases and approaches those of healthy individuals. Apparently, in INRs treated for hepatitis C, the immune system recovery takes time and may be incomplete.

Keywords

HIV Infections, Hepatitis C, Antiretroviral Therapy, Highly Active, Immunological non-response, Direct-acting antivirals, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Systemic inflammation

References

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